AIMC Topic: Bleomycin

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Deciphering the cellular and molecular landscape of pulmonary fibrosis through single-cell sequencing and machine learning.

Journal of translational medicine Jan 2, 2025
Pulmonary fibrosis is characterized by progressive lung scarring, leading to a decline in lung function and an increase in morbidity and mortality. This study leverages single-cell sequencing and machine learning to unravel the complex cellular and m...
Lung Single-Cell Analysis Mice Animals Male Fibroblasts Pulmonary Fibrosis Gene Expression Regulation Bleomycin Mice, Inbred C57BL Humans Machine Learning
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Integrating machine learning with bioinformatics for predicting idiopathic pulmonary fibrosis prognosis: developing an individualized clinical prediction tool.

Experimental biology and medicine (Maywood, N.J.) Dec 23, 2024
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease with a poor prognosis. Its non-specific clinical symptoms make accurate prediction of disease progression challenging. This study aimed to develop molecular-level prognostic m...
Computational Biology Disease Models, Animal Idiopathic Pulmonary Fibrosis Transcriptome Female Mice Precision Medicine Humans Male Aged Animals Prognosis Bleomycin Machine Learning Middle Aged Mice, Inbred C57BL
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Microscopic computed tomography with AI-CNN-powered image analysis: the path to phenotype bleomycin-induced lung injury.

American journal of physiology. Cell physiology Apr 22, 2024
Bleomycin (BLM)-induced lung injury in mice is a valuable model for investigating the molecular mechanisms that drive inflammation and fibrosis and for evaluating potential therapeutic approaches to treat the disease. Given high variability in the BL...
Neural Networks, Computer Animals Male Lung Artificial Intelligence Phenotype Collagen Lung Injury X-Ray Microtomography Bleomycin Mice Mice, Inbred C57BL Disease Models, Animal Pulmonary Fibrosis
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Specneuzhenide improves bleomycin-induced pulmonary fibrosis in mice via AMPK-dependent reduction of PD-L1.

Phytomedicine : international journal of phytotherapy and phytopharmacology Dec 30, 2023
BACKGROUND: Pulmonary fibrosis (PF) is an escalating global health issue, characterized by rising rates of morbidity and mortality annually. Consequently, further investigation of potential damage mechanisms and potential preventive strategies for PF...
Mice, Inbred C57BL Fibroblasts Pulmonary Fibrosis AMP-Activated Protein Kinases Cell Line Mice Disease Models, Animal Bleomycin Molecular Docking Simulation B7-H1 Antigen Epithelial-Mesenchymal Transition Animals Transforming Growth Factor beta1 Male Lung
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A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy.

Respiratory research May 9, 2023
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease progression and response to candidate drugs in various animal models of human disease, but manual image processing is still highly time-consuming and prone to operat...
Pulmonary Fibrosis X-Ray Microtomography Disease Models, Animal Bleomycin Humans Reproducibility of Results Deep Learning Mice Animals
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Wet-dry-wet drug screen leads to the synthesis of TS1, a novel compound reversing lung fibrosis through inhibition of myofibroblast differentiation.

Cell death & disease Dec 17, 2021
Therapies halting the progression of fibrosis are ineffective and limited. Activated myofibroblasts are emerging as important targets in the progression of fibrotic diseases. Previously, we performed a high-throughput screen on lung fibroblasts and s...
Lung Diseases Transfection High-Throughput Screening Assays Drug Screening Assays, Antitumor Cell Differentiation Drug Discovery Mice Bleomycin Myofibroblasts Humans Machine Learning Idiopathic Pulmonary Fibrosis Animals
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