AIMC Topic: Nerve Degeneration

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3-Dimensional Immunostaining and Automated Deep-Learning Based Analysis of Nerve Degeneration.

International journal of molecular sciences Nov 26, 2022
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease driven by inflammation and demyelination in the brain, spinal cord, and optic nerve. Optic neuritis, characterized by inflammation and demyelination of the optic nerve, is a sympt...
Mice Inflammation Optic Neuritis Disease Models, Animal Animals Nerve Degeneration Mice, Inbred C57BL Deep Learning Encephalomyelitis, Autoimmune, Experimental Neurodegenerative Diseases Multiple Sclerosis
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Data-driven identification of diagnostically useful extrastriatal signal in dopamine transporter SPECT using explainable AI.

Scientific reports Nov 25, 2021
This study used explainable artificial intelligence for data-driven identification of extrastriatal brain regions that can contribute to the interpretation of dopamine transporter SPECT with I-FP-CIT in parkinsonian syndromes. A total of 1306 I-FP-CI...
Humans Neural Networks, Computer Nerve Degeneration Predictive Value of Tests Radiopharmaceuticals Image Interpretation, Computer-Assisted Tomography, Emission-Computed, Single-Photon Tropanes Reproducibility of Results Dopamine Plasma Membrane Transport Proteins Parkinson Disease Brain Diagnosis, Differential Retrospective Studies
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Deep Learning to Decipher the Progression and Morphology of Axonal Degeneration.

Cells Sep 25, 2021
Axonal degeneration (AxD) is a pathological hallmark of many neurodegenerative diseases. Deciphering the morphological patterns of AxD will help to understand the underlying mechanisms and develop effective therapies. Here, we evaluated the progressi...
Deep Learning Disease Models, Animal Neurodegenerative Diseases Humans Animals Nerve Degeneration Neurons Cell Death Axons
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A machine learning approach to screen for preclinical Alzheimer's disease.

Neurobiology of aging May 4, 2021
Combining multimodal biomarkers could help in the early diagnosis of Alzheimer's disease (AD). We included 304 cognitively normal individuals from the INSIGHT-preAD cohort. Amyloid and neurodegeneration were assessed on F-florbetapir and F-fluorodeox...
Nerve Degeneration Electroencephalography Alzheimer Disease Positron-Emission Tomography Hippocampus Neuropsychological Tests Apolipoprotein E4 Mass Screening Follow-Up Studies Magnetic Resonance Imaging Cohort Studies Genotype Machine Learning Biomarkers Female Aged Aged, 80 and over Male Humans
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Machine learning-based decision tree classifier for the diagnosis of progressive supranuclear palsy and corticobasal degeneration.

Neuropathology and applied neurobiology Apr 7, 2021
AIMS: This study aimed to clarify the different topographical distribution of tau pathology between progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and establish a machine learning-based decision tree classifier.
Aged, 80 and over Male Middle Aged Decision Trees Diagnosis, Differential tau Proteins Brain Female Aged Humans Machine Learning Inclusion Bodies Neurofibrillary Tangles Corticobasal Degeneration Supranuclear Palsy, Progressive Nerve Degeneration
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The role of neuroinflammation in the pathogenesis of glaucoma neurodegeneration.

Progress in brain research Aug 13, 2020
The chapter is a review enclosed in the volume "Glaucoma: A pancitopatia of the retina and beyond." No cure exists for glaucoma. Knowledge on the molecular and cellular alterations underlying glaucoma neurodegeneration (GL-ND) includes innovative and...
Biological Therapy Artificial Intelligence Nerve Degeneration Humans Inflammation Glaucoma Uveitis
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Neuro4Neuro: A neural network approach for neural tract segmentation using large-scale population-based diffusion imaging.

NeuroImage May 31, 2020
Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized fr...
Male Middle Aged Dementia Reproducibility of Results Humans Neural Networks, Computer Aged Brain White Matter Female Imaging, Three-Dimensional Diffusion Tensor Imaging Image Processing, Computer-Assisted Nerve Degeneration Neuroimaging
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