Current approaches to estimating cell trajectories, tumor progression dynamics, and cell population diversity of tumor microenvironment often depend on single-cell RNA sequencing, which is costly and resource intensive. To address this limitation, we...
Recently, dementia research has primarily concentrated on using Magnetic Resonance Imaging (MRI) to develop learning models in processing and analyzing brain data. However, these models often cannot provide early detection of affected brain regions. ...
Facioscapulohumeral muscular dystrophy (FSHD) is a genetic neuromuscular disorder characterized by progressive muscle degeneration with substantial variability in severity and progression patterns. FSHD is a highly heterogeneous disease; however, cur...
Digital technologies for monitoring motor symptoms of Parkinson's Disease (PD) underwent a strong evolution during the past years. Although it has been shown for several devices that derived digital gait features can reliably discriminate between hea...
The Journal of clinical investigation
Jul 15, 2025
Pancreatic ductal adenocarcinoma (PDAC) is known to progress from one of two main precursor lesions: pancreatic intraepithelial neoplasia (PanIN) or intraductal papillary mucinous neoplasm (IPMN). The poor survival rates for patients with PDAC, even ...
BACKGROUND: To investigate the association between the Dietary Inflammatory Index (DII), biological aging, and the staging and mortality of cardiovascular-kidney-metabolic (CKM) syndrome.
OBJECTIVES: To identify and characterise distinct subgroups of patients with asthma with severe acute exacerbations (AEs) by using a multistep clustering methodology that combines supervised and unsupervised machine learning.
European journal of cancer (Oxford, England : 1990)
Jul 5, 2025
BACKGROUND: Cancer recurrence and progression, once seen as markers of poor prognosis, are now considered manageable aspects of long-term care. Advances in treatment have extended survival, emphasizing the need for representative epidemiological info...
BACKGROUND: Pancreatic cancer (PC) represents a highly heterogeneous malignancy with poor prognosis, where precise molecular subtyping facilitates comprehensive understanding of disease progression.
Kidney pathology of immunoglobulin A nephropathy (IgAN), which is the key finding of both diagnosis and risk stratification, involves labor-intensive manual interpretation as well as unavoidable interpreter-dependent variabilities. We propose artific...
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