Organophosphorus pesticide (OP) residues in agricultural products, herbal medicines and environment have attracted increasing concerns because they cause high healthy risk. Herein, a tyrosinase-mediated photoinduced electron transfer system was const...
Impulsivity, i.e. irresistibility in the execution of actions, may be prominent in Parkinson's disease (PD) patients who are treated with dopamine precursors or dopamine receptor agonists. In this study, we combine clinical investigations with comput...
Neural networks : the official journal of the International Neural Network Society
25863288
We introduce a spiking neural network of the basal ganglia capable of learning stimulus-action associations. We model learning in the three major basal ganglia pathways, direct, indirect and hyperdirect, by spike time dependent learning and consideri...
The basal ganglia are a collection of subcortical nuclei thought to underlie a wide variety of vertebrate behavior. Although a great deal is known about the functional and physiological properties of the basal ganglia, relatively few models have been...
At around 7 months of age, human infants begin to reliably produce well-formed syllables containing both consonants and vowels, a behavior called canonical babbling. Over subsequent months, the frequency of canonical babbling continues to increase. H...
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
29449446
Simultaneous reconstruction of activity and attenuation using the maximum-likelihood reconstruction of activity and attenuation (MLAA) augmented by time-of-flight information is a promising method for PET attenuation correction. However, it still suf...
Predicting drug-protein interactions (DPIs) for target proteins involved in dopamine pathways is a very important goal in medicinal chemistry. We can tackle this problem using Molecular Docking or Machine Learning (ML) models for one specific protein...
Journal of child psychology and psychiatry, and allied disciplines
30252127
Most psychiatric disorders emerge during childhood and adolescence. This is also a period that coincides with the brain undergoing substantial growth and reorganisation. However, it remains unclear how a heightened vulnerability to psychiatric disord...
Unbiased estimates of neuron numbers within substantia nigra are crucial for experimental Parkinson's disease models and gene-function studies. Unbiased stereological counting techniques with optical fractionation are successfully implemented, but ar...