Noncoding RNAs have increasingly recognized roles in critical molecular mechanisms of disease. However, the noncoding genome of Drosophila melanogaster, one of the most powerful disease model organisms, has been understudied. Here, we present FLYNC-F...
, the fruit fly, uses the neurotransmitters dopamine and octopamine to mediate learning, enabling adaptive behaviors such as reward seeking and punishment avoidance. Their colocalization in the mushroom bodies makes it challenging to study their indi...
Quantifying animal behavior is pivotal for identifying the neuronal and genetic mechanisms involved. Computational approaches have enabled automated analysis of complex behaviors such as aggression and courtship in . However, existing approaches rely...
The nervous system flexibly processes information under different conditions. To do this, neural networks frequently rely on uniform expression of modulatory receptors by distinct classes of neurons to fine tune the computations supported by each neu...
Critical periods (CPs) during the development of neural networks are widely documented. Activity manipulation during open CPs leads to debilitating effects to the mature neural network. Detailed understanding of the contribution of CPs to network dev...
Understanding how organisms detect environmental humidity remains a fundamental problem in sensory biology. While specialised sensory neurons in insect antennae can detect changes in humidity, the mechanism underlying this ability is not fully unders...
Neurodegenerative diseases are devastating conditions characterized by progressive cognitive decline with few available treatments. Neurodegeneration can be quantified in vertebrate and invertebrate models of disease by analysis of vacuolation - the ...
Embryo development is driven by the spatiotemporal dynamics of complex gene regulatory networks. Uncovering these dynamics requires simultaneous tracking of multiple fluctuating molecular species over time, which exceeds the capabilities of tradition...
Understanding developmental changes in neuronal lineages is crucial to elucidate how they assemble into functional neural networks. Studies investigating nervous system development in model systems have only focused on select regions of the CNS due t...
In , olfactory encoding in the mushroom body (MB) involves thousands of Kenyon cells (KCs) processing inputs from hundreds of projection neurons (PNs). Recent data challenge the notion of random PN-to-KC connectivity, revealing preferential connectio...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.