Journal of controlled release : official journal of the Controlled Release Society
Nov 27, 2025
Glioblastoma (GBM) is an aggressive central nervous system (CNS) malignancy with a poor prognosis and limited responses to conventional therapies. RNA-based therapeutics, with their gene-targeting specificity, present a promising avenue for GBM treat...
The purpose of this work was to formulate and characterize pH-sensitive, surfactant-based nanomicelles for the targeted delivery of Oxaliplatin to breast cancer cells. A secondary aim was to utilize machine learning (ML) models to interpolate and dis...
In cancer combination therapy, micro-robot systems that integrate multiple therapeutic functions have emerged as a key direction for overcoming the limitations of traditional treatments. This study proposes a magnetic thermosensitive hydrogel capsule...
Journal of controlled release : official journal of the Controlled Release Society
Nov 20, 2025
'Character is destiny' holds apt resonance in determining the biofate of nanocarriers, where the formation of biomolecular or protein corona (PC) around nanocarriers bestows a "new biological identity" different from their synthetic identity. The acq...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
International journal of pharmaceutics
Nov 15, 2025
Oral cancer remains one of the most aggressive malignancies worldwide, with high recurrence and limited treatment outcomes due to late diagnosis and ineffective targeting of tumor microenvironments. Stem cell-based hydrogel therapies have emerged as ...
International journal of pharmaceutics
Nov 15, 2025
Transdermal drug delivery systems (TDDS) offer a painless and non-invasive route of administration but are limited by the skin barrier. Microneedles (MNs) have been shown to overcome this challenge and enable the delivery of small molecules, peptides...
Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a...
Journal of controlled release : official journal of the Controlled Release Society
Nov 8, 2025
The human immune system defends against pathogens, regulates inflammation, and supports tissue repair, but overactivity or dysregulation can compromise these functions. While wearable devices have been explored for immune modulation, conventional des...
Allergic skin disease conditions represent a significant global health challenge, with conventional therapies frequently associated with local dermal irritation and systemic adverse effects. Nanotechnology-enabled transdermal drug delivery platforms ...
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