AIMC Topic: Antibiotics, Antineoplastic

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Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

ACS applied materials & interfaces Jun 16, 2025
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...
Animals Cell Line, Tumor Mice Cell Proliferation Humans Drug Delivery Systems Hydrogels Alginates Mitomycin Antibiotics, Antineoplastic Urinary Bladder Neoplasms Drug Carriers Robotics
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Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity.

Biology direct Oct 9, 2023
BACKGROUND: Anthracyclines including doxorubicin are essential components of many cancer chemotherapy regimens, but their cardiotoxicity severely limits their use. New strategies for treating anthracycline-induced cardiotoxicity (AIC) are still neede...
Anthracyclines Artificial Intelligence Animals Deep Learning Antibiotics, Antineoplastic Cardiotoxicity DNA Doxorubicin
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The Value of Convolutional Neural Network-Based Magnetic Resonance Imaging Image Segmentation Algorithm to Guide Targeted Controlled Release of Doxorubicin Nanopreparation.

Contrast media & molecular imaging Jul 26, 2021
There was an investigation of the auxiliary role of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image segmentation algorithm in MRI image-guided targeted drug therapy of doxorubicin nanomaterials so that the value of d...
Antibiotics, Antineoplastic Nanoparticle Drug Delivery System Doxorubicin Drug Liberation Delayed-Action Preparations Image Processing, Computer-Assisted Follow-Up Studies Magnetic Resonance Imaging Female Aged Adult Case-Control Studies Liver Neoplasms Male Middle Aged Humans Neural Networks, Computer Algorithms Prognosis
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Magnetically Actuated Drug Delivery Helical Microrobot with Magnetic Nanoparticle Retrieval Ability.

ACS applied materials & interfaces Apr 20, 2021
Therapeutic drug delivery microrobots capable of accurate targeting using an electromagnetic actuation (EMA) system are being developed. However, these drug delivery microrobots include a large number of magnetic nanoparticles (MNPs) for accurate EMA...
Biocompatible Materials Magnetics Antibiotics, Antineoplastic Magnetite Nanoparticles Microscopy, Fluorescence Doxorubicin Humans Cell Survival Robotics Drug Delivery Systems Cell Line
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Label-Free Estimation of Therapeutic Efficacy on 3D Cancer Spheres Using Convolutional Neural Network Image Analysis.

Analytical chemistry Oct 24, 2019
Despite recent advances in cancer treatment, developing better therapeutic reagents remains an essential task for oncologists. To accurately characterize drug efficacy, 3D cell culture holds great promise as opposed to conventional 2D monolayer cultu...
Dose-Response Relationship, Drug Cell Survival Drug Screening Assays, Antitumor Doxorubicin Optical Imaging Structure-Activity Relationship Equipment Design Breast Neoplasms Image Processing, Computer-Assisted Cell Proliferation Humans Neural Networks, Computer Tumor Cells, Cultured Antibiotics, Antineoplastic Microfluidic Analytical Techniques
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Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes.

International journal of nanomedicine Dec 19, 2017
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically ...
Thermogravimetry Doxorubicin Drug Liberation Xenograft Model Antitumor Assays Animals Mice, Nude Phospholipids Tissue Distribution Antibiotics, Antineoplastic Nanotubes Clay X-Ray Diffraction Microscopy, Electron, Transmission Aluminum Silicates Stomach Neoplasms Drug Delivery Systems Humans
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Machine learning algorithms to control concentrations of carbon nanocomplexes in a biological medium via optical absorption spectroscopy: how to choose and what to expect?

Applied optics Sep 20, 2021
A solution of spectroscopic inverse problems, implying determination of target parameters of the research object via analysis of spectra of various origins, is an overly complex task, especially in case of strong variability of the research object. O...
Humans Male Microscopy, Confocal Nanoparticles Carbon Machine Learning Algorithms Female Antibiotics, Antineoplastic Spectrophotometry, Infrared Nanoconjugates Drug Carriers Doxorubicin Healthy Volunteers
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Development and validation of a LC-FL method for the simultaneous determination of doxorubicin and celecoxib in nanoparticulate fixed dose combination (NanoFDC).

Die Pharmazie Oct 1, 2017
An isocratic reversed phase HPLC method for the simultaneous determination of doxorubicine (DOX) and celecoxib (CXB) out of a nanoparticulate fixed dose combination (NanoFDC) was developed and validated. Linearity of the results was demonstrated from...
Doxorubicin Celecoxib Cyclooxygenase 2 Inhibitors Antibiotics, Antineoplastic Drug Combinations Limit of Detection Chromatography, High Pressure Liquid Reproducibility of Results Nanoparticles Antineoplastic Combined Chemotherapy Protocols
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