Trained Immunity is the nonspecific (pathogen agnostic) memory of innate immune cells, characterized by altered responses upon secondary stimulation. This review provides a RoadMap for the discovery and development of therapeutics targeting Trained I...
Journal of pharmacokinetics and pharmacodynamics
Dec 16, 2025
The landscape of pharmaceutical research and drug development is undergoing a significant evolution, with Model-Informed Drug Discovery and Development (MID3) as a transformative approach to accelerate innovation. Realizing the full potential of MID3...
Since Pfizer developed the mRNA vaccine for COVID-19 by leveraging artificial intelligence (AI) for designing the vaccine, integrating AI and allied domains in the drug development process has escalated at an unimaginable rate. Owing to the complex a...
Model-informed drug development (MIDD) plays an important role in pharmacometrics by leveraging mathematical models to optimize drug dosing strategies. Traditional methods such as nonlinear mixed effects modeling (NONMEM) have long been the gold stan...
The liquid and solid formulations of self-nano-emulsifying drug delivery systems (SNEDDS) have garnered significant attention in the pharmaceutical field for their ability to enhance the solubility and absorption of hydrophobic drugs. While both liqu...
Physical stability of an active pharmaceutical ingredient (API) is a key consideration in the development of a pharmaceutical drug. Solution conditions such as pH, excipient concentrations, and storage temperatures can impact the physical stability o...
Drug development is an expensive endeavor, with costs averaging $879.3 million and only 14.3% of them ultimately securing regulatory approval. One fundamental challenge is ensuring that the enrolled patient population in a clinical trial accurately r...
Molecular dynamics (MD) simulations have emerged as a powerful and extensively employed tool in biomedical research, offering insights into intricate biomolecular processes such as structural flexibility and molecular interactions, and playing a pivo...
Cancer is a leading cause of death worldwide and a major burden on the healthcare system. Current treatment methods are limited as they have low selectivity, unspecific targeting and increasing multidrug resistance. Therefore, newer modes of therapeu...
The field of solid-state pharmaceutics comprises a broad range of investigations into various structural aspects of pharmaceutical solids, establishing a rational structure-property correlation. These solid systems allow the tunability of the physico...
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