AIMC Topic: Drug Liberation

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Investigations into the use of machine learning to predict drug dosage form design to obtain desired release profiles for 3D printed oral medicines.

Pharmaceutical development and technology Feb 16, 2023
Three-dimensional (3D) printing, digitalization, and artificial intelligence (AI) are gaining increasing interest in modern medicine. All three aspects are combined in personalized medicine where 3D-printed dosage forms are advantageous because of th...
Artificial Intelligence Drug Liberation Technology, Pharmaceutical Polyvinyl Alcohol Printing, Three-Dimensional Tablets Machine Learning
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A 3D Tumor-Mimicking In Vitro Drug Release Model of Locoregional Chemoembolization Using Deep Learning-Based Quantitative Analyses.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Feb 15, 2023
Primary liver cancer, with the predominant form as hepatocellular carcinoma (HCC), remains a worldwide health problem due to its aggressive and lethal nature. Transarterial chemoembolization, the first-line treatment option of unresectable HCC that e...
Drug Liberation Chemoembolization, Therapeutic Liver Neoplasms Carcinoma, Hepatocellular Humans Deep Learning
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Formulation design and optimization of cationic-charged liposomes of brimonidine tartrate for effective ocular drug delivery by design of experiment (DoE) approach.

Drug development and industrial pharmacy May 19, 2022
OBJECTIVE: The present study was aimed to design and optimize brimonidine tartrate (BRT) loaded cationic-charged liposome formulation with enhanced trans-corneal drug permeation, prolonged corneal residence, and sustained drug release for effective o...
Brimonidine Tartrate Liposomes Drug Delivery Systems Lipids Particle Size Drug Liberation Drug Carriers Cornea
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Preformulation studies of thymopentin: analytical method development, physicochemical properties, kinetic degradation investigations and formulation perspective.

Drug development and industrial pharmacy Mar 15, 2022
Thymopentin (TP5) is a synthetic pentapeptide with immunomodulatory properties. Given the previously described poor absorption of TP5, preformulation data is required to support effective formulation development. In this manuscript, an analytical met...
Thymopentin Kinetics Drug Liberation Solubility Half-Life
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Magnetic Biohybrid Microrobot Multimers Based on Cells for Enhanced Targeted Drug Delivery.

ACS applied materials & interfaces Jan 12, 2022
Magnetic micro-/nanorobots have been regarded as a promising platform for targeted drug delivery, and tremendous strategies have been developed in recent years. However, realizing precise and efficient drug delivery in vivo still remains challenging,...
Drug Carriers Robotics Hydrogen-Ion Concentration Humans Cell Survival Magnetic Fields Magnetics Chlorella Drug Liberation HeLa Cells Ferrosoferric Oxide Doxorubicin Biocompatible Materials
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Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment.

ACS nano Oct 19, 2021
Microrobots have attracted considerable attention due to their extensive applications in microobject manipulation and targeted drug delivery. To realize more complex micro-/nanocargo manipulation (., encapsulation and release) in biological applicati...
Doxorubicin Drug Liberation HeLa Cells Neoplasms Robotics Humans Drug Delivery Systems
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Machine learning predicts 3D printing performance of over 900 drug delivery systems.

Journal of controlled release : official journal of the Controlled Release Society Jul 30, 2021
Three-dimensional printing (3DP) is a transformative technology that is advancing pharmaceutical research by producing personalized drug products. However, advances made via 3DP have been slow due to the lengthy trial-and-error approach in optimizati...
Printing, Three-Dimensional Drug Liberation Technology, Pharmaceutical Artificial Intelligence Machine Learning Drug Delivery Systems
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The Value of Convolutional Neural Network-Based Magnetic Resonance Imaging Image Segmentation Algorithm to Guide Targeted Controlled Release of Doxorubicin Nanopreparation.

Contrast media & molecular imaging Jul 26, 2021
There was an investigation of the auxiliary role of convolutional neural network- (CNN-) based magnetic resonance imaging (MRI) image segmentation algorithm in MRI image-guided targeted drug therapy of doxorubicin nanomaterials so that the value of d...
Humans Follow-Up Studies Neural Networks, Computer Magnetic Resonance Imaging Female Drug Liberation Aged Algorithms Delayed-Action Preparations Adult Antibiotics, Antineoplastic Doxorubicin Prognosis Case-Control Studies Male Nanoparticle Drug Delivery System Liver Neoplasms Middle Aged Image Processing, Computer-Assisted
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Investigation into liquisolid system processability based on the SeDeM Expert System approach.

International journal of pharmaceutics Jun 30, 2021
Liquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evalu...
Powders Expert Systems Povidone Drug Liberation Tablets Solubility
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Microstructure, Quality, and Release Performance Characterization of Long-Acting Polymer Implant Formulations with X-Ray Microscopy and Quantitative AI Analytics.

Journal of pharmaceutical sciences Jun 2, 2021
Long-acting implants are typically formulated using carrier(s) with specific physical and chemical properties, along with the active pharmaceutical ingredient (API), to achieve the desired daily exposure for the target duration of action. In characte...
Polymers Drug Liberation Microscopy Artificial Intelligence X-Rays
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