AIMC Topic: Epstein-Barr Virus Infections

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An interpretable machine learning prognostic system for locoregionally advanced nasopharyngeal carcinoma based on tumor burden features.

Oral oncology May 21, 2021
OBJECTIVES: We aimed to build a survival system by combining a highly-accurate machine learning (ML) model with explainable artificial intelligence (AI) techniques to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma (NPC...
Humans Tumor Burden Chemoradiotherapy Nasopharyngeal Neoplasms Nasopharyngeal Carcinoma Epstein-Barr Virus Infections Herpesvirus 4, Human Machine Learning Prognosis
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MRI-Based Deep-Learning Model for Distant Metastasis-Free Survival in Locoregionally Advanced Nasopharyngeal Carcinoma.

Journal of magnetic resonance imaging : JMRI Aug 9, 2020
BACKGROUND: Distant metastasis is the primary cause of treatment failure in locoregionally advanced nasopharyngeal carcinoma (LANPC).
Humans Retrospective Studies Herpesvirus 4, Human Magnetic Resonance Imaging Deep Learning Epstein-Barr Virus Infections Nasopharyngeal Neoplasms Chemoradiotherapy Nasopharyngeal Carcinoma
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Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma.

Chinese journal of cancer Dec 29, 2017
BACKGROUND: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively unde...
Neoplasm Staging Survival Analysis Lymphatic Metastasis DNA Copy Number Variations Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms ROC Curve DNA, Viral Epstein-Barr Virus Infections Herpesvirus 4, Human Female Male Humans Prognosis
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AI-Driven Drug Target Screening Platform Identified Oncogene CACNA2D1 Activated by Enhancer Infestation in Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

International journal of molecular sciences May 14, 2025
The management of nasopharyngeal cancer (NPC) is rapidly evolving, with immune checkpoint inhibitors emerging as a prominent treatment approach. However, drug development targeting specific molecular and cellular abnormalities in NPC has slowed. Rece...
Cell Line, Tumor Mice Artificial Intelligence Animals Enhancer Elements, Genetic Herpesvirus 4, Human Humans Oncogenes Calcium Channels Nasopharyngeal Carcinoma Promoter Regions, Genetic Gene Expression Regulation, Neoplastic Nasopharyngeal Neoplasms Epstein-Barr Virus Infections
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Investigating the Link between Type 2 Diabetes and Epstein-Barr Virus: a Machine Learning and Mendelian Randomization.

Clinical laboratory May 1, 2025
BACKGROUND: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that is known to cause infectious mononucleosis and is associated with several autoimmune diseases and cancers through immune system dysregulation and chronic inflammatory mechanisms.
Middle Aged Diabetes Mellitus, Type 2 Adult Male Epstein-Barr Virus Infections Herpesvirus 4, Human Mendelian Randomization Analysis Antibodies, Viral DNA, Viral Humans Machine Learning Immunoglobulin G Female
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Exploring genetic and immune cell dynamics in systemic lupus erythematosus patients with Epstein-Barr virus infection via machine learning.

Rheumatology (Oxford, England) May 1, 2025
OBJECTIVES: EBV is a widespread virus implicated in various diseases, including SLE. However, the specific genes and pathways altered in SLE patients with EBV infection remain unclear. We aimed to identify key genes and immune cells in SLE patients w...
Humans Epstein-Barr Virus Infections Herpesvirus 4, Human Lupus Erythematosus, Systemic Gene Expression Profiling Membrane Proteins Machine Learning Female
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