AIMC Topic: Estrogens

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Machine learning for RNA sequencing-based intrinsic subtyping of breast cancer.

Scientific reports Aug 21, 2020
Stratification of breast cancer (BC) into molecular subtypes by multigene expression assays is of demonstrated clinical utility. In principle, global RNA-sequencing (RNA-seq) should enable reconstructing existing transcriptional classifications of BC...
Receptors, Estrogen Recurrence Neoplasms, Hormone-Dependent Machine Learning Estrogens Prognosis Carcinoma Female Datasets as Topic Breast Neoplasms Biomarkers, Tumor Logistic Models Sequence Analysis, RNA Humans
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The Use of Transdermal Estrogen in Castrate-resistant, Steroid-refractory Prostate Cancer.

Clinical genitourinary cancer Oct 10, 2019
BACKGROUND: Androgen-deprivation therapy is the mainstay of treatment for metastatic prostate cancer. Corticosteroids and estrogens are also useful agents in castration-resistant prostate cancer (CRPC). However, oral estrogens are associated with thr...
Aged, 80 and over Quality of Life Humans Drug Resistance, Neoplasm Estrogens Male Prognosis Follow-Up Studies Middle Aged Prostatic Neoplasms, Castration-Resistant Aged Steroids Administration, Cutaneous
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Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry.

Analytica chimica acta Dec 21, 2018
Estrogens regulate many diverse biological processes in health and disease. They circulate at a wide range of concentrations in females generating several active metabolites (hydroxy and methoxyestrogens). The metabolites are assumed to be present in...
Tandem Mass Spectrometry Solid Phase Extraction Humans Piperazine Estrogens Linear Models Chromatography, Liquid Blood Chemical Analysis Limit of Detection
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Effect of 17β-estradiol on milk production, hormone secretion, and mammary gland gene expression in dairy cows.

Journal of dairy science Dec 21, 2017
Estradiol inhibits milk production in dairy cows. The present study evaluated the effect of 17β-estradiol (E2) injections on prolactin (PRL) secretion and the mammary gland response to this hormone. Eight mid-lactation cows were used in a crossover d...
Mammary Glands, Animal Lactation Milk Prolactin Cattle Female Estradiol Animals Estrogens Gene Expression
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Overweight postmenopausal women with different plasma estradiol concentrations present with a similar pattern of energy expenditure and substrate oxidation rate before and after a fatty meal challenge.

Clinical nutrition ESPEN Jun 2, 2016
Menopause-related withdrawal of ovarian estrogens is associated with reduced energy metabolism and overall impairment of substrate oxidation. Estradiol's withdrawal after menopause is associated with a reduction in energy metabolism and impaired subs...
Child Estradiol Estrogens Body Mass Index Obesity Oxidation-Reduction Body Composition Humans Female Middle Aged Calorimetry, Indirect Carbohydrate Metabolism Dietary Fats Lipid Metabolism Menopause Energy Metabolism Postmenopause Eating Meals Postprandial Period Intra-Abdominal Fat
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Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry.

Talanta Dec 29, 2015
Estrogens circulate at concentrations less than 20pg/mL in men and postmenopausal women, presenting analytical challenges. Quantitation by immunoassay is unreliable at these low concentrations. Liquid chromatography tandem mass spectrometry (LC-MS/MS...
Benzenesulfonates Estrone Chromatography, Liquid Tandem Mass Spectrometry Solid Phase Extraction Spectrometry, Mass, Electrospray Ionization Postmenopause Pyridinium Compounds Premenopause Male Middle Aged Estradiol Estrogens Aged, 80 and over Young Adult Adult Humans Female Reproducibility of Results Aged
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Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

Proteomics Jun 11, 2015
With growing abundance and awareness of endocrine disrupting compounds (EDCs) in the environment, there is a need for accurate and reliable detection of EDC exposure. Our objective in the present study was to observe differences within and between th...
Animals Male Estradiol Estrogens Female Chromatography, Liquid Blood Proteins Blotting, Western Tandem Mass Spectrometry Proteomics Proteome Support Vector Machine Bass Kininogens Vitellogenins Nanotechnology Sex Factors Fish Proteins
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Noninferiority of Artificial Intelligence-Assisted Analysis of Ki-67 and Estrogen/Progesterone Receptor in Breast Cancer Routine Diagnostics.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Mar 1, 2023
Image analysis assistance with artificial intelligence (AI) has become one of the great promises over recent years in pathology, with many scientific studies being published each year. Nonetheless, and perhaps surprisingly, only few image AI systems ...
Humans Estrogens Receptors, Estrogen Artificial Intelligence Receptors, Progesterone Female Ki-67 Antigen Reproducibility of Results Breast Neoplasms
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