A substantial portion of lung cancer-associated genetic elements in East Asian populations remains unidentified, underscoring the need for large-scale genome-wide studies, particularly on non-coding regulation. We conducted a whole genome sequencing ...
Auranofin, an FDA-approved antirheumatic gold drug, has gained ongoing interest in clinical studies for treating advanced or recurrent tumors. However, gold ion's dynamic thiol exchange nature strongly attenuates its bioactivity due to the fast forma...
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...
Understanding the role of Social Determinants of Health (SDoH) in pregnancy outcomes is critical for improving maternal and infant health yet extracting SDoH from unstructured electronic health records remains challenging. We trained and evaluated na...
This study uses artificial intelligence (AI) for differentiation between salivary gland tumours (SGT) using digitised Haematoxylin and Eosin stained whole-slide images (WSI). Machine learning (ML) classifiers were developed and tested using 320 scann...
Adherence to antiretroviral therapy (ART) is critical for HIV treatment success, yet the impact of tuberculosis preventive therapy (TPT) remains inadequately understood. Using observational data from 4152 HIV patients in Ethiopia (2005-2024), we appl...
BACKGROUND: Abnormal hedgehog (Hh) signaling is linked to preeclampsia (PE). This study aimed to identify Hh-related diagnostic biomarkers for PE and assess the role of immune infiltration.
OBJECTIVE: This study aims to develop an objective and efficient diagnostic model for schizophrenia (SCZ) by integrating electroencephalogram (EEG) signals with deep learning techniques. Building on previous research, γ wave activity is selected as a...
BMC medical informatics and decision making
Aug 8, 2025
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...
COVID-19 has posed a significant global health challenge, affecting individuals across all age groups. While extensive research has focused on adults, pediatric patients exhibit distinct clinical characteristics that necessitate specialized predictiv...
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