AIMC Topic: Fluorescence Resonance Energy Transfer
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DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning.
eLife
Nov 3, 2020
Single-molecule Förster Resonance energy transfer (smFRET) is an adaptable method for studying the structure and dynamics of biomolecules. The development of high throughput methodologies and the growth of commercial instrumentation have outpaced the...
False Positive Reactions
Single Molecule Imaging
Normal Distribution
User-Computer Interface
Fluorescent Dyes
Signal Processing, Computer-Assisted
Kinetics
Molecular Dynamics Simulation
Nanotechnology
Markov Chains
Fluorescence Resonance Energy Transfer
Software
Algorithms
Reproducibility of Results
Deep Learning
Identification of Catecholamine Neurotransmitters Using a Fluorescent Electronic Tongue.
ACS chemical neuroscience
Dec 19, 2019
Catecholamine neurotransmitters, specifically, dopamine (DA), epinephrine (EP), and norepinephrine (NE), are known as substantial indicators of various neurological diseases. Developing rapid detection methods capable of simultaneously screening thei...
Integrated structural modeling and super-resolution imaging resolve GPCR oligomers.
Progress in molecular biology and translational science
Dec 6, 2019
Formation of G protein-coupled receptors (GPCRs) dimers and higher order oligomers represents a key mechanism in pleiotropic signaling, yet how individual protomers function within oligomers remains poorly understood. For the Class A/rhodopsin subfam...
Ligands
Fluorescence Resonance Energy Transfer
Crystallography, X-Ray
Protein Interaction Mapping
Support Vector Machine
Receptors, G-Protein-Coupled
Mutation
Molecular Dynamics Simulation
Protein Structure, Secondary
Protein Multimerization
Allosteric Site
Humans
Neural Networks, Computer
Machine Learning
Software
Algorithms
Animals
Protein Binding
Computational Biology
Photoluminescence-tunable fluorescent carbon dots-deposited silver nanoparticle for detection and killing of bacteria.
Materials science & engineering. C, Materials for biological applications
Dec 22, 2018
Innovative methods to detect and kill pathogenic bacteria have a pivotal role in the eradication of infectious diseases and the prevention of the growth of antibiotic-resistant bacteria. The combination of fluorescent carbon dots (FCDs) with silver n...
A Novel Morphological Marker for the Analysis of Molecular Activities at the Single-cell Level.
Cell structure and function
Jun 29, 2018
For more than a century, hematoxylin and eosin (H&E) staining has been the de facto standard for histological studies. Consequently, the legacy of histological knowledge is largely based on H&E staining. Due to the recent advent of multi-photon excit...
Linking of single-molecule experiments with molecular dynamics simulations by machine learning.
eLife
May 3, 2018
Single-molecule experiments and molecular dynamics (MD) simulations are indispensable tools for investigating protein conformational dynamics. The former provide data, such as donor-acceptor distances, whereas the latter give atomistic information, ...
Label-free detection of histone based on cationic conjugated polymer-mediated fluorescence resonance energy transfer.
Talanta
Dec 5, 2017
A simple and homogeneous histone assay is developed based on histone-induced DNA compressing coupled with cationic conjugated polymer (CCP)-mediated fluorescence resonance energy transfer (FRET). In this strategy, the CCP serves as the FRET donor and...
Fluorescence resonance energy transfer aptasensor between nanoceria and graphene quantum dots for the determination of ochratoxin A.
Analytica chimica acta
Aug 24, 2017
In the present work, colloidal cerium oxide nanoparticles (nanoceria) and graphene quantum dots (GQDs) were firstly synthesized by sol-gel method and pyrolysis respectively, which all have a uniform nano-size and significant fluorescence emission. Du...
A "Turn-on-off-on" fluorescence switch based on quantum dots and gold nanoparticles for discriminative detection of ovotransferrin.
Talanta
Dec 25, 2015
A novel strategy for ovotransferrin (OVT) detection by tracing the "on-off-on" fluorescence signals of quantum dots (QDs) and gold nanoparticles (AuNPs) utilizing fluorescence measurements were established in this article. The immune interaction betw...
Dual-mode nanosensor for sensitive detection of methotrexate based on fluorescence technology and deep learning algorithms.
Analytica chimica acta
Aug 8, 2025
BACKGROUND: Methotrexate (MTX) in the body can result in severe, potentially life-threatening side effects. As a result, it is imperative to establish a dependable, precise, and specific method for detecting MTX. However, conventional sensors often s...
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