Accurately inferring the genome-wide landscape of recombination rates in natural populations is a central aim in genomics, as patterns of linkage influence everything from genetic mapping to understanding evolutionary history. Here, we describe recom...
Access to large-scale genomics datasets has increased the utility of hypothesis-free genome-wide analyses. However, gene signals are often insufficiently powered to reach experiment-wide significance, triggering a process of laborious triaging of gen...
Journal of the American Medical Informatics Association : JAMIA
May 1, 2020
OBJECTIVE: Predicting patient outcomes using healthcare/genomics data is an increasingly popular/important area. However, some diseases are rare and require data from multiple institutions to construct generalizable models. To address institutional d...
Cancer is well recognized as a complex disease with dysregulated molecular networks or modules. Graph- and rule-based analytics have been applied extensively for cancer classification as well as prognosis using large genomic and other data over the p...
MOTIVATION: Cancer subtype classification has the potential to significantly improve disease prognosis and develop individualized patient management. Existing methods are limited by their ability to handle extremely high-dimensional data and by the i...
The advent of high-throughput genomic technologies has resulted in the accumulation of massive amounts of genomic information. However, biologists are challenged with how to effectively analyze these data. Machine learning can provide tools for bette...
MOTIVATION: Interactions among cis-regulatory elements such as enhancers and promoters are main driving forces shaping context-specific chromatin structure and gene expression. Although there have been computational methods for predicting gene expres...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2020
Genome3D consortium is a collaborative project involving protein structure prediction and annotation resources developed by six world-leading structural bioinformatics groups, based in the United Kingdom (namely Blundell, Murzin, Gough, Sternberg, Or...
[Rinsho ketsueki] The Japanese journal of clinical hematology
Jan 1, 2020
Precision medicine in oncology uses genomic data to provide the right intervention in the right patients at the right time. For this purpose, next-generation sequencing (NGS) is an indispensable tool. However, further innovations are necessary, inclu...
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