MDM2 (Mouse Double Minute 2), a fundamental governor of the p53 tumor suppressor pathway, has garnered significant attention as a favorable target for cancer therapy. Recent years have witnessed the development and synthesis of potent MDM2 inhibitors...
Phenotyping of animals is a routine task in agriculture which can provide large datasets for the functional annotation of genomes. Using the livestock farming sector to study complex traits enables genetics researchers to fully benefit from the digit...
This study presents a dual investigation of Salmonella enterica subspecies I, focusing on serovar prediction and core genome characteristics. We utilized two large genomic datasets (panX and NCBI Pathogen Detection) to test machine learning methods f...
The exponential growth of microbial genome data presents unprecedented opportunities for unlocking the potential of microorganisms. The burgeoning field of pangenomics offers a framework for extracting insights from this big biological data. Recent a...
Sepsis is a life-threatening systemic inflammatory syndrome characterized by a complex immune biphasic imbalance. Monitoring of immune status has not yet been implemented in clinical practice due to lack of direct therapeutic utility. Immune dysregul...
INTRODUCTION: In recent years, artificial intelligence (AI) tools have become widely studied for thyroid ultrasonography (USG) classification. The real-world applicability of these developed tools as pre-operative diagnostic aids is limited due to mo...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
A significantly low success rate of human clinical studies has long been attributed to a capability gap, namely, an ineffective translation of the animal data to the human context. To bridge this capability gap, several correcting measures have been ...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Artificial intelligence (AI) and machine learning (ML) have advanced in several areas and fields of life; however, its progress in the field of genomics is not matching the levels others have achieved. Challenges include but are not limited to the ha...
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2025
Single-cell omics technologies have revolutionized the study of long non-coding RNAs (lncRNAs), offering unprecedented resolution in elucidating their expression dynamics, cell-type specificity, and associated gene regulatory networks (GRNs). Concurr...
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Jan 1, 2025
Precision medicine significantly enhances patients prognosis, offering personalized treatments. Particularly for metastatic cancer, incorporating primary tumor location into the diagnostic process greatly improves survival rates. However, traditional...