AIMC Topic: Glucose

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Single-cell Raman imaging reveals fructose impairs brown adipocyte differentiation.

Biosensors & bioelectronics
Brown adipose tissue (BAT) plays a pivotal role in energy expenditure and metabolic health, yet the influence of specific sugars like fructose on brown adipocyte development remains poorly understood. Here, we employ high-speed line-illumination Rama...

YOLOv5-aided paper-based microfluidic intelligent sensing platform for multiplex sweat biomarker analysis.

Biosensors & bioelectronics
Sweat, a biofluid rich in various biomarkers, offers significant potential for non-invasive health monitoring and disease screening. Colorimetric detection is well-suited for multi-analyte quantification and point-of-care testing in sweat analysis, w...

An artificial intelligence-assisted, kilometer-scale wireless and wearable biochemical sensing platform for monitoring of key biomarkers in urine.

Biosensors & bioelectronics
Wearable biochemical sensors enabling non-invasive monitoring of biomarkers in bodily fluids play a pivotal role in advancing personalized healthcare. The state-of-the-art wireless and wearable biochemical sensors still suffer from large form factors...

Modification and applications of glucose oxidase: optimization strategies and high-throughput screening technologies.

World journal of microbiology & biotechnology
Glucose oxidase (GOD), an oxidoreductase (EC 1.1.3.4), catalyzes the oxidation of β-D-glucose to gluconic acid using molecular oxygen as the electron acceptor, with concomitant generation of hydrogen peroxide. Owing to its versatile catalytic propert...

Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery.

Molecular medicine (Cambridge, Mass.)
BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disease frequently accompanied by disturbances in glucose metabolism, which further complicate the disease prognosis. This study aims to explore the role of PFKFB3, a key glycolytic enzyme,...

Dynamic mode decomposition for analysis and prediction of metabolic oscillations from time-lapse imaging of cellular autofluorescence.

Scientific reports
Oscillations are a common phenomenon in cell biology. They are based on non-linear coupling of biochemical reactions and can show rich dynamic behavior as found in, for example, glycolysis of yeast cells. Here, we show that dynamic mode decomposition...

Spatial patterns of hepatocyte glucose flux revealed by stable isotope tracing and multi-scale microscopy.

Nature communications
Metabolic homeostasis requires engagement of catabolic and anabolic pathways consuming nutrients that generate and consume energy and biomass. Our current understanding of cell homeostasis and metabolism, including how cells utilize nutrients, comes ...

In-silico guided identification and studies of potential FFAR4 agonists for type 2 diabetes mellitus therapy.

Expert opinion on drug discovery
BACKGROUND: The activation of free fatty acid receptor 4 (FFAR4) enhances insulin sensitivity and glucose uptake while mitigating inflammation. It is a promising therapeutic approach for managing type 2 diabetes mellitus (T2DM).

Fully Wearable Devices for Real-Time Health Monitoring and Multimodal Sensing in Nanomedicine Using Multiplexed Green Biofuels.

Nano letters
Fully wearable devices are crucial for real-time health monitoring, but existing devices often lack stable power, on-site signal processing, and multimodal sensing. To overcome these limitations, we introduce the first self-powered and fully wearable...

Multimodal Wearable Sensing for Biomechanics and Biomolecules Enabled by the M-MPM/VCFs@Ag Interface with Machine Learning Pipeline.

ACS sensors
The addition sensing device of sweat to wearable biostress sensors would eliminate the need for using multiple gadgets for healthcare analysis. Due to the distinct package fashion of sensor interface for biostress and biomolecule, achieving permeabil...