AIMC Topic: Glycosylation
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O-glycosylation site prediction for by combining properties and sequence features with support vector machine.
Journal of bioinformatics and computational biology
Nov 19, 2021
O-glycosylation is a protein posttranslational modification important in regulating almost all cells. It is related to a large number of physiological and pathological phenomena. Recognizing O-glycosylation sites is the key to further investigating t...
Mapping the glycosyltransferase fold landscape using interpretable deep learning.
Nature communications
Sep 27, 2021
Glycosyltransferases (GTs) play fundamental roles in nearly all cellular processes through the biosynthesis of complex carbohydrates and glycosylation of diverse protein and small molecule substrates. The extensive structural and functional diversifi...
Protein glycation - biomarkers of metabolic dysfunction and early-stage decline in health in the era of precision medicine.
Redox biology
Feb 26, 2021
Protein glycation provides a biomarker in widespread clinical use, glycated hemoglobin HbA (A1C). It is a biomarker for diagnosis of diabetes and prediabetes and of medium-term glycemic control in patients with established diabetes. A1C is an early-s...
Incorporating a transfer learning technique with amino acid embeddings to efficiently predict N-linked glycosylation sites in ion channels.
Computers in biology and medicine
Jan 7, 2021
Glycosylation is a dynamic enzymatic process that attaches glycan to proteins or other organic molecules such as lipoproteins. Research has shown that such a process in ion channel proteins plays a fundamental role in modulating ion channel functions...
Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates.
Nature communications
Sep 25, 2020
Organic synthesis methodology enables the synthesis of complex molecules and materials used in all fields of science and technology and represents a vast body of accumulated knowledge optimally suited for deep learning. While most organic reactions i...
Machine Learning Classifies Core and Outer Fucosylation of N-Glycoproteins Using Mass Spectrometry.
Scientific reports
Jan 15, 2020
Protein glycosylation is known to be involved in biological progresses such as cell recognition, growth, differentiation, and apoptosis. Fucosylation of glycoproteins plays an important role for structural stability and function of N-linked glycoprot...
Conservation region finding for influenza A viruses by machine learning methods of N-linked glycosylation sites and B-cell epitopes.
Mathematical biosciences
Jun 17, 2019
Influenza type A, a serious infectious disease of the human respiratory tract, poses an enormous threat to human health worldwide. It leads to high mortality rates in poultry, pigs, and humans. The primary target identity regions for the human immune...
Serum N-Glycosylation in Parkinson's Disease: A Novel Approach for Potential Alterations.
Molecules (Basel, Switzerland)
Jun 13, 2019
In this study, we present the application of a novel capillary electrophoresis (CE) method in combination with label-free quantitation and support vector machine-based feature selection (support vector machine-estimated recursive feature elimination ...
Candida albicans-derived mannoproteins activate NF-κB in reporter cells expressing TLR4, MD2 and CD14.
PloS one
Dec 27, 2017
The ability of soluble C. albicans 20A (serotype A) mannoprotein (CMP) to serve as a ligand for toll-like receptor 4 (TLR4) and its co-receptors was examined using commercially available and stably-transfected HEK293 cells that express human TLR4, MD...
New insights into the efficiency of thymol synergistic effect with p-cymene in inhibiting advanced glycation end products: A multi-way analysis based on spectroscopic and electrochemical methods in combination with molecular docking study.
Journal of pharmaceutical and biomedical analysis
Dec 24, 2017
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glyca...
Spectrophotometry, Ultraviolet
Cymenes
Thymol
Lysine
Electrochemical Techniques
Serum Albumin, Bovine
Monoterpenes
Hypoglycemic Agents
Kinetics
Glycation End Products, Advanced
Arginine
Protein Processing, Post-Translational
Drug Synergism
Protein Conformation
Structure-Activity Relationship
Binding Sites
Molecular Docking Simulation
Protein Binding
Glycosylation
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