BACKGROUND: The high heterogeneity of Parkinson's disease (PD) hinders personalized interventions. Brain structure reflects damage and neuroplasticity and is one of the biological bases of symptomatology. Subtyping PD in the framework of brain struct...
The Dark Triad (DT), encompassing narcissism, Machiavellianism and psychopathy traits, poses significant societal challenges. Understanding the neural underpinnings of these traits is crucial for developing effective interventions and preventive stra...
Multimodal neuroimaging is an emerging field that leverages multiple sources of information to diagnose specific brain disorders, especially when deep learning-based AI algorithms are applied. The successful combination of different brain imaging mod...
Cerebral cortex (New York, N.Y. : 1991)
May 2, 2024
Brain energy budgets specify metabolic costs emerging from underlying mechanisms of cellular and synaptic activities. While current bottom-up energy budgets use prototypical values of cellular density and synaptic density, predicting metabolism from ...
Ageing is a heterogeneous multisystem process involving different rates of decline in physiological integrity across biological systems. The current study dissects the unique and common variance across body and brain health indicators and parses inte...
Cerebral cortex (New York, N.Y. : 1991)
Jan 5, 2023
This study aimed to analyse cerebral grey matter changes in mild cognitive impairment (MCI) using voxel-based morphometry and to diagnose early Alzheimer's disease using deep learning methods based on convolutional neural networks (CNNs) evaluating t...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Jul 1, 2022
The APOE-ε4 allele is a known genetic risk for Alzheimer's disease (AD). Thus, it can be reasoned that the APOE-ε4 allele would also impact neurodegeneration-associated structural brain changes. Here we probe if the APOE-ε4 genotype directly modulate...
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Nov 1, 2021
Deep brain nuclei are closely related to the pathogenesis of neurodegenerative diseases. Automatic segmentation for brain nuclei plays a significant role in aging and disease-related assessment. Quantitative susceptibility mapping (QSM), as a novel M...
Based on whole-brain gray matter volume (GMV), we used relevance vector regression to predict the Rey's Auditory Verbal Learning Test Delayed Recall (AVLT-DR) scores of individual amnestic mild cognitive impairment (aMCI) patient. The whole-brain GMV...
Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is a common type of pediatric epilepsy. We sought to evaluate whether the combination of voxel-based morphometry (VBM) and support vector machine (SVM), a machine learning method, was...