BACKGROUND: Integrated health data are foundational for secondary use, research, and policymaking. However, data quality issues-such as missing values and inconsistencies-are common due to the heterogeneity of health data sources. Existing frameworks...
BACKGROUND: Although an increasing number of bedside medical devices are equipped with wireless connections for reliable notifications, many nonnetworked devices remain effective at detecting abnormal patient conditions and alerting medical staff thr...
BACKGROUND: KMT2B-related dystonia is a childhood-onset movement disorder. This study investigated a novel KMT2B gene variant using whole exome sequencing (WES) and bioinformatics analysis, and expanded the known clinical spectrum of KMT2B-related dy...
INTRODUCTION: This study aimed to validate an artificial intelligence (AI)-based automated image analysis for three-dimensional (3D) characterization of impacted canine position. In addition, it compared clinical treatment plans developed using conve...
Cancer immunology, immunotherapy : CII
Nov 12, 2025
Matrix stiffness is a defining feature of pancreatic ductal adenocarcinoma (PDAC) and drives malignant progression through mechanisms that remain poorly understood. Using an ensemble machine learning approach, we integrated multiomics data from 886 p...
Journal of computer-aided molecular design
Nov 12, 2025
Deep generative models may detect novel compounds with favourable features, exhibiting chemical design potential. Traditional single-stage variational autoencoders (VAEs) lack validity, uniqueness, and biologically meaningful distribution alignment. ...
The rapid development of spatial transcriptomics (ST) has made it possible to effectively integrate gene expression and spatial information of cells and accurately identify spatial domains. A large number of deep learning (DL)-based methods have been...
BACKGROUND: While interventions have been designed which use extended reality (XR) technology in promoting physical, mental and social well-being through cultural heritage experiences, well-defined methodologies for the assessment of such interventio...
Asthma is a chronic respiratory disease characterized by wheezing and difficulty breathing, which disproportionally affects 4.7 million children in the U.S. Currently, there is a lack of asthma predictive models for youth with good performance. This ...
OBJECTIVE: With the global increase in obesity rates and lifestyle changes, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a prevalent chronic liver disorder, affecting approximately 25% of the global population. This dis...
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