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NMFGO: Gene Function Prediction via Nonnegative Matrix Factorization with Gene Ontology.

IEEE/ACM transactions on computational biology and bioinformatics Jul 30, 2018
Gene Ontology (GO) is a controlled vocabulary of terms that describe molecule function, biological roles, and cellular locations of gene products (i.e., proteins and RNAs), it hierarchically organizes more than 43,000 GO terms via the direct acyclic ...
Genes Arabidopsis Molecular Sequence Annotation Computational Biology Humans Saccharomyces cerevisiae Gene Ontology Algorithms
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Application of Artificial Neural Network in miRNA Biomarker Selection and Precise Diagnosis of Colorectal Cancer.

Iranian biomedical journal Jul 30, 2018
BACKGROUND: The early diagnosis of colorectal cancer (CRC) is associated with improved survival rates, and development of novel non-invasive, sensitive, and specific diagnostic tests is highly demanded. The objective of this paper was to identify com...
Biomarkers, Tumor ROC Curve MicroRNAs Regression Analysis Humans Neural Networks, Computer Colorectal Neoplasms Area Under Curve Internet
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Normalizing Spontaneous Reports Into MedDRA: Some Experiments With MagiCoder.

IEEE journal of biomedical and health informatics Jul 30, 2018
Text normalization into medical dictionaries is useful to support clinical tasks. A typical setting is pharmacovigilance (PV). The manual detection of suspected adverse drug reactions (ADRs) in narrative reports is time consuming and natural language...
Medical Informatics Drug-Related Side Effects and Adverse Reactions Humans Data Mining Natural Language Processing Pharmacovigilance
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Diagnostic performance of machine-learning-based computed fractional flow reserve (FFR) derived from coronary computed tomography angiography for the assessment of myocardial ischemia verified by invasive FFR.

The international journal of cardiovascular imaging Jul 30, 2018
To explore the diagnostic performance of a machine-learning-based (ML-based) computed fractional flow reserve (cFFR) derived from coronary computed tomography angiography (CCTA) in identifying ischemia-causing lesions verified by invasive FFR in cath...
Fractional Flow Reserve, Myocardial Cardiac Catheters Male Middle Aged Severity of Illness Index Humans Machine Learning Reproducibility of Results Retrospective Studies Coronary Vessels Predictive Value of Tests Aged Computed Tomography Angiography Female Multidetector Computed Tomography Coronary Angiography Coronary Stenosis Aged, 80 and over Radiographic Image Interpretation, Computer-Assisted
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Improved surgical instruments without coupled motion used in minimally invasive surgery.

The international journal of medical robotics + computer assisted surgery : MRCAS Jul 30, 2018
BACKGROUND: Unlike a manual surgical instrument, a surgical instrument used in robot-assisted minimally invasive surgery (MIS) is configured with a wrist to improve flexibility in surgical operation. However, this configuration has a shortcoming that...
Surgical Instruments Gallbladder Kidney Robotics Minimally Invasive Surgical Procedures Equipment Design Reproducibility of Results Surgery, Computer-Assisted Animals Motion Swine Humans
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How far have we come with contextual data integration in drug discovery?

Expert opinion on drug discovery Jul 30, 2018
Artificial Intelligence Algorithms Drug Discovery Humans
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Prioritising references for systematic reviews with RobotAnalyst: A user study.

Research synthesis methods Jul 30, 2018
Screening references is a time-consuming step necessary for systematic reviews and guideline development. Previous studies have shown that human effort can be reduced by using machine learning software to prioritise large reference collections such t...
Machine Learning Software Algorithms Humans Data Interpretation, Statistical Switzerland Review Literature as Topic Data Mining Retrospective Studies Reproducibility of Results Cluster Analysis
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Insight Analysis of Promiscuous Estrogen Receptor α-Ligand Binding by a Novel Machine Learning Scheme.

Chemical research in toxicology Jul 30, 2018
Estrogen receptor α (ERα) plays a significant role in occurrence of breast cancer and may cause various adverse side-effects when ERα is an off-target protein. A theoretical model was derived to predict the binding affinity of ERα using the pharmacop...
Protein Conformation Protein Binding Estrogen Receptor alpha Support Vector Machine Models, Molecular Ligands Quantitative Structure-Activity Relationship Crystallography, X-Ray Machine Learning Humans Computer Simulation Reproducibility of Results
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Crowdsourcing image analysis for plant phenomics to generate ground truth data for machine learning.

PLoS computational biology Jul 30, 2018
The accuracy of machine learning tasks critically depends on high quality ground truth data. Therefore, in many cases, producing good ground truth data typically involves trained professionals; however, this can be costly in time, effort, and money. ...
Pilot Projects Image Processing, Computer-Assisted Internet Data Accuracy Crops, Agricultural Food Supply Machine Learning Crowdsourcing Algorithms Humans Phenotype
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Current trends of digital solutions for diabetes management.

Diabetes & metabolic syndrome Jul 29, 2018
Industry 4.0 is an updated concept of smart production, which is identified with the fourth industrial revolution and the emergence of cyber-physical systems. Industry 4.0 is the next stage in the digitization of productions and industries, where suc...
Internet Delivery of Health Care Humans Disease Management Big Data Artificial Intelligence Diabetes Mellitus Machine Learning
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