Humans

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Predicting human splicing branchpoints by combining sequence-derived features and multi-label learning methods.

BMC bioinformatics Dec 1, 2017
BACKGROUND: Alternative splicing is the critical process in a single gene coding, which removes introns and joins exons, and splicing branchpoints are indicators for the alternative splicing. Wet experiments have identified a great number of human sp...
Machine Learning Computational Biology Base Sequence Humans RNA Splicing Exons Position-Specific Scoring Matrices Genome, Human Introns Nucleotide Motifs
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Predicting enhancers with deep convolutional neural networks.

BMC bioinformatics Dec 1, 2017
BACKGROUND: With the rapid development of deep sequencing techniques in the recent years, enhancers have been systematically identified in such projects as FANTOM and ENCODE, forming genome-wide landscapes in a series of human cell lines. Nevertheles...
Humans Models, Genetic DNA Genome, Human Enhancer Elements, Genetic Neural Networks, Computer Databases, Factual Machine Learning Genomics Algorithms Computational Biology
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Exploring the Impact of Food on the Gut Ecosystem Based on the Combination of Machine Learning and Network Visualization.

Nutrients Dec 1, 2017
Prebiotics and probiotics strongly impact the gut ecosystem by changing the composition and/or metabolism of the microbiota to improve the health of the host. However, the composition of the microbiota constantly changes due to the intake of daily di...
Prebiotics Gastrointestinal Tract Food Probiotics Models, Biological Microbiota Machine Learning Humans Ferns Male
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Medical subdomain classification of clinical notes using a machine learning-based natural language processing approach.

BMC medical informatics and decision making Dec 1, 2017
BACKGROUND: The medical subdomain of a clinical note, such as cardiology or neurology, is useful content-derived metadata for developing machine learning downstream applications. To classify the medical subdomain of a note accurately, we have constru...
Clinical Decision-Making Unified Medical Language System Humans Medical Records Natural Language Processing Machine Learning
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Vitamin D Deficiency and Atopic Dermatitis: Consider Disease, Race, and Body Mass.

Skinmed Dec 1, 2017
Vitamin D deficiency causes rickets, but has been associated with various diseases, including atopic dermatitis (AD). This study analyzes serum vitamin D in pediatric medical center patients with AD and potential confounding factors. At Cardinal Glen...
Dermatitis, Atopic Asian Skin Pigmentation Young Adult White People Male Black or African American Humans Infant Racial Groups Child, Preschool Retrospective Studies Vitamin D Prevalence United States Child Female Vitamin D Deficiency Severity of Illness Index Infant, Newborn Body Mass Index Cystic Fibrosis Adolescent
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Cytoprotective Effects of Cell-Permeable Bifunctional Antioxidant Enzyme, GST-TAT-SOD, against Cisplatin-Induced Cell Damage.

Oxidative medicine and cellular longevity Nov 30, 2017
GST-TAT-SOD, a cell-permeable bifunctional antioxidant enzyme, is a potential selective radioprotector. This study aimed to investigate the cytoprotective activity of GST-TAT-SOD against cisplatin-induced damage. The current study showed that cisplat...
Reactive Oxygen Species Protective Agents Cisplatin Superoxide Dismutase Glutathione Transferase Humans Apoptosis Recombinant Fusion Proteins Peptides Cell Line Malondialdehyde
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Detecting event-related changes in organizational networks using optimized neural network models.

PloS one Nov 30, 2017
Organizational external behavior changes are caused by the internal structure and interactions. External behaviors are also known as the behavioral events of an organization. Detecting event-related changes in organizational networks could efficientl...
Algorithms Humans Neural Networks, Computer
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Advanced patient transfer assist device with intuitive interaction control.

Assistive technology : the official journal of RESNA Nov 29, 2017
This research aims to improve patient transfers by developing a new type of advanced robotic assist device. It has multiple actuated degrees of freedom and a powered steerable base to maximize maneuverability around obstacles. An intuitive interface ...
Wheelchairs Self-Help Devices Caregivers Patient Transfer Humans Robotics
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Acceptance and perceived usefulness of robots to assist with activities of daily living and healthcare tasks.

Assistive technology : the official journal of RESNA Nov 29, 2017
As the number of older adults living with chronic conditions continues to rise, they will require assistance with activities of daily living (ADL) and healthcare tasks to continue living independently in their homes. One proposed solution to assist w...
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Humans Male Young Adult Middle Aged Self-Help Devices Adult Robotics Adolescent Female Cross-Sectional Studies Activities of Daily Living Aged Aged, 80 and over
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Assessment of the model refinement category in CASP12.

Proteins Nov 29, 2017
We here report on the assessment of the model refinement predictions submitted to the 12th Experiment on the Critical Assessment of Protein Structure Prediction (CASP12). This is the fifth refinement experiment since CASP8 (2008) and, as with the pre...
Protein Conformation Protein Folding Sequence Analysis, Protein Proteins Models, Molecular Machine Learning Humans Crystallography, X-Ray Algorithms Computational Biology
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