AIMC Topic: Humans

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Multi-modal signal integration for enhanced sleep stage classification: Leveraging EOG and 2-channel EEG data with advanced feature extraction.

Artificial intelligence in medicine
This paper introduces an innovative approach to sleep stage classification, leveraging a multi-modal signal integration framework encompassing Electrooculography (EOG) and two-channel electroencephalography (EEG) data. We explore the utility of vario...

Cangrelor and AVN-944 as repurposable candidate drugs for hMPV: analysis entailed by AI-driven in silico approach.

Molecular diversity
Human metapneumovirus (hMPV) primarily causes respiratory tract infections in young children and older adults. According to the 2024 Human Pneumonia Etiology Research for Child Health (PERCH) study, hMPV is the second leading common cause of pneumoni...

Multi-objective optimization framework to plan laser ablation procedure for prostate tumors through a genetic algorithm.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVES: Prostate cancer is the most common form of cancer in the male population. While the survival rate is high, many patients undergo surgical procedures for prostate cancer that might never progress to clinical significance. As...

Deep Learning-enhanced Opportunistic Osteoporosis Screening in Ultralow-Voltage (80 kV) Chest CT: A Preliminary Study.

Academic radiology
RATIONALE AND OBJECTIVES: To explore the feasibility of deep learning (DL)-enhanced, fully automated bone mineral density (BMD) measurement using the ultralow-voltage 80 kV chest CT scans performed for lung cancer screening.

Identification of pyroptosis-related gene S100A12 as a potential diagnostic biomarker for sepsis through bioinformatics analysis and machine learning.

Molecular immunology
Sepsis is a non-discriminatory inflammatory reaction that can result in a diverse array of organ dysfunctions, which can be fatal. Pyroptosis is a programmed mechanism of cell death that is distinguishable from apoptosis and other forms of cellular d...

Machine learning approach to single cell transcriptomic analysis of Sjogren's disease reveals altered activation states of B and T lymphocytes.

Journal of autoimmunity
Sjogren's Disease (SjD) is an autoimmune disorder characterized by salivary and lacrimal gland dysfunction and immune cell infiltration leading to gland inflammation and destruction. Although SjD is a common disease, its pathogenesis is not fully und...

Optimizing stroke lesion segmentation: A dual-approach using Gaussian mixture models and nnU-Net.

Computers in biology and medicine
Machine learning-based stroke lesion segmentation models are widely used in biomedical imaging, but their ability to detect treatment effects remains largely unexplored. Gaussian Mixture Models (GMM) and nnU-Net are among the most prominent and well-...

Automatic ultrasound image alignment for diagnosis of pediatric distal forearm fractures.

International journal of computer assisted radiology and surgery
PURPOSE: The study aims to develop an automatic method to align ultrasound images of the distal forearm for diagnosing pediatric fractures. This approach seeks to bypass the reliance on X-rays for fracture diagnosis, thereby minimizing radiation expo...

Compositional transformations can reasonably introduce phenotype-associated values into sparse features.

mSystems
UNLABELLED: Gihawi et al. (mBio 14:e01607-23, 2023, https://doi.org/10.1128/mbio.01607-23) argued that the analysis of tumor-associated microbiome data by Poore et al. (Nature 579:567-574, 2020, https://doi.org/10.1038/s41586-020-2095-1) is invalid b...

Accurate identification and mechanistic evaluation of pathogenic missense variants with .

Proceedings of the National Academy of Sciences of the United States of America
Understanding the effects of missense mutations or single amino acid variants (SAVs) on protein function is crucial for elucidating the molecular basis of diseases/disorders and designing rational therapies. We introduce here , a machine learning too...