A new UPLC-MS/MS method (method A), for simultaneous determination of alogliptin (ALN) and metformin (MET) in their recently approved pharmaceutical combination Kazano® tablets, was developed and compared to a new UHPLC-UV method (method B). Concerni...
Studies in health technology and informatics
Jan 1, 2017
In healthcare, applying deep learning models to electronic health records (EHRs) has drawn considerable attention. This sequential nature of EHR data make them wellmatched for the power of Recurrent Neural Network (RNN). In this poster, we propose "D...
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Jan 1, 2017
Metformin as an oral antidiabetic drug (OAD) is not recommended in renal failure due to the presumed risk of lactic acidosis though it has advantages in cardiovascular protection with a low risk of hypoglycemia. Few studies have measured lactic acid ...
European heart journal. Cardiovascular Imaging
Dec 1, 2016
BACKGROUND: Arterial stiffness is associated with increased risk for cardiovascular disease. The purpose of this study is to investigate the arterial stiffness and myocardial deformation in patients with poorly controlled diabetes mellitus type 2 bef...
Iranian journal of allergy, asthma, and immunology
Dec 1, 2016
Signaling AMP-activated protein kinase (AMPK), an energy sensing enzyme, has been implicated in controlling inflammation. In this study we investigated whether activation of AMPK by metformin could protect the lung from lipopolysaccharide (LPS)-induc...
BACKGROUND: Quality improvement efforts are frequently tied to patients achieving ≥80% medication adherence. However, there is little empirical evidence that this threshold optimally predicts important health outcomes.
Combinatorial chemistry & high throughput screening
Jan 1, 2015
The ligand-based virtual screening of combinatorial libraries employs a number of statistical modeling and machine learning methods. A comprehensive analysis of the application of these methods for the diversity oriented virtual screening of biologic...