AIMC Topic: Influenza Vaccines

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Predicting the short-term success of human influenza virus variants with machine learning.

Proceedings. Biological sciences
Seasonal influenza viruses are constantly changing and produce a different set of circulating strains each season. Small genetic changes can accumulate over time and result in antigenically different viruses; this may prevent the body's immune system...

The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system.

Scientific data
Machine learning has the potential to identify novel biological factors underlying successful antibody responses to influenza vaccines. The first attempts have revealed a high level of complexity in establishing influenza immunity, and many different...

SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses.

Journal of immunology (Baltimore, Md. : 1950)
Machine learning holds considerable promise for understanding complex biological processes such as vaccine responses. Capturing interindividual variability is essential to increase the statistical power necessary for building more accurate predictive...

Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure.

eLife
Optical super-resolution microscopy techniques enable high molecular specificity with high spatial resolution and constitute a set of powerful tools in the investigation of the structure of supramolecular assemblies such as viruses. Here, we report o...

Immunogenicity of Concentrated and Purified Inactivated Avian Influenza Vaccine Formulation.

Archives of Razi Institute
Avian influenza (AI) H9N2 is a low pathogenic virus subtype belonging to Orthomyxoviridae family. Given the prevalence of this subtype as an infectious agent in poultry industry, special attention has been always directed toward the development of va...

Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults.

Clinical nutrition (Edinburgh, Scotland)
BACKGROUND & AIMS: Mortality resulting from influenza (flu) virus infections occurs primarily in the elderly through declining immunity. Studies in mice have suggested beneficial effects of selenium (Se) supplementation on immunity to flu but similar...

Clinical course of H1N1-vaccine-related narcolepsy.

Sleep medicine
OBJECTIVE: To follow and analyze the clinical course and quality of life of Pandemrix H1N1-vaccine-related narcolepsy (pNT1).

Humanoid robotics in health care: An exploration of children's and parents' emotional reactions.

Journal of health psychology
A new non-pharmacological method of distraction was tested with 57 children during their annual flu vaccination. Given children's growing enthusiasm for technological devices, a humanoid robot was programmed to interact with them while a nurse admini...

Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...

Optimizing influenza vaccine allocation: A predictive analytics approach for informed public health planning.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE: Excessive purchasing of influenza vaccine can lead to costly overages and waste of resources. Insufficient quantities, however, can jeopardize population health. Our project aimed to use predictive analytics to determine the influenza vaccin...