AIMC Topic: Mutation Rate

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A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans.

PLoS genetics Aug 26, 2024
Chemical mutagenesis-driven forward genetic screens are pivotal in unveiling gene functions, yet identifying causal mutations behind phenotypes remains laborious, hindering their high-throughput application. Here, we reveal a non-uniform mutation rat...
Whole Genome Sequencing Mutagenesis Mutation Rate Animals Mutation Chromosome Mapping Kinesins Ethyl Methanesulfonate Caenorhabditis elegans Caenorhabditis elegans Proteins Machine Learning Phenotype
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Self-replicating artificial neural networks give rise to universal evolutionary dynamics.

PLoS computational biology Mar 28, 2024
In evolutionary models, mutations are exogenously introduced by the modeler, rather than endogenously introduced by the replicator itself. We present a new deep-learning based computational model, the self-replicating artificial neural network (SeRAN...
Mutation Mutation Rate Biological Evolution Genotype Neural Networks, Computer Evolution, Molecular
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Coot-Lion optimized deep learning algorithm for COVID-19 point mutation rate prediction using genome sequences.

Computer methods in biomechanics and biomedical engineering Sep 5, 2023
In this study, a deep quantum neural network (DQNN) based on the Lion-based Coot algorithm (LBCA-based Deep QNN) is employed to predict COVID-19. Here, the genome sequences are subjected to feature extraction. The fusion of features is performed usin...
Humans COVID-19 Deep Learning Genome, Viral Mutation Rate Algorithms SARS-CoV-2 Point Mutation
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Machine Learning Identifies Pan-Cancer Landscape of Nrf2 Oxidative Stress Response Pathway-Related Genes.

Oxidative medicine and cellular longevity Feb 17, 2022
BACKGROUND: Oxidative stress produced a large amount of reactive oxygen species (ROS), which played a pivotal role in balanced ability and determining cell fate. The activated Nrf2 signaling pathway that responds to the excessive ROS regulated the ex...
Mutation Rate NF-E2-Related Factor 2 Case-Control Studies Oxidative Stress Signal Transduction Reactive Oxygen Species Gene Expression Regulation, Neoplastic Neoplasms Transcriptome Tumor Microenvironment Biomarkers, Tumor Humans Machine Learning Prognosis Phenotype Survival Rate
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Predicting haplogroups using a versatile machine learning program (PredYMaLe) on a new mutationally balanced 32 Y-STR multiplex (CombYplex): Unlocking the full potential of the human STR mutation rate spectrum to estimate forensic parameters.

Forensic science international. Genetics Jun 29, 2020
We developed a new mutationally well-balanced 32 Y-STR multiplex (CombYplex) together with a machine learning (ML) program PredYMaLe to assess the impact of STR mutability on haplogourp prediction, while respecting forensic community criteria (high D...
Male Multiplex Polymerase Chain Reaction Haplotypes Mutation Rate Polymorphism, Single Nucleotide Humans Forensic Genetics Chromosomes, Human, Y Machine Learning DNA Fingerprinting Microsatellite Repeats
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Genotoxicity evaluation of titanium dioxide nanoparticles using the mouse lymphoma assay and the Ames test.

Mutation research. Genetic toxicology and environmental mutagenesis Dec 1, 2018
Titanium dioxide nanoparticles (TiO-NPs) are widely used in the cosmetics, health, and food industries, but their safety and genotoxicity remain a matter of debate. We investigated whether TiO-NPs could induce gene mutations in mouse lymphoma L5178Y ...
Mutation Rate Metal Nanoparticles Mice Mutagenesis Animals Titanium DNA Damage Salmonella typhimurium Mutagenicity Tests Cell Line, Tumor
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Time series computational prediction of vaccines for influenza A H3N2 with recurrent neural networks.

Journal of bioinformatics and computational biology Feb 1, 2020
Influenza viruses are persistently threatening public health, causing annual epidemics and sporadic pandemics due to rapid viral evolution. Vaccines are used to prevent influenza infections but the composition of the influenza vaccines have to be upd...
Influenza A Virus, H3N2 Subtype Neural Networks, Computer Interrupted Time Series Analysis Computational Biology Humans Influenza Vaccines Epitopes Mutation Rate Influenza, Human Viral Proteins
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