AIMC Topic: Knowledge Bases

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A knowledgebase of the human Alu repetitive elements.

Journal of biomedical informatics Jan 28, 2016
Alu elements are the most abundant retrotransposons in the human genome with more than one million copies. Alu repeats have been reported to participate in multiple processes related with genome regulation and compartmentalization. Moreover, they hav...
Humans Computational Biology Epigenesis, Genetic Genome, Human Promoter Regions, Genetic Gene Ontology Chromatin DNA Methylation Alu Elements Knowledge Bases
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A Natural Language Interface Concordant with a Knowledge Base.

Computational intelligence and neuroscience Jan 21, 2016
The discordance between expressions interpretable by a natural language interface (NLI) system and those answerable by a knowledge base is a critical problem in the field of NLIs. In order to solve this discordance problem, this paper proposes a meth...
Geography Humans Algorithms Information Storage and Retrieval Databases, Factual Semantics Natural Language Processing Language Biological Ontologies Knowledge Bases
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Spark, an application based on Serendipitous Knowledge Discovery.

Journal of biomedical informatics Dec 28, 2015
Findings from information-seeking behavior research can inform application development. In this report we provide a system description of Spark, an application based on findings from Serendipitous Knowledge Discovery studies and data structures known...
Models, Theoretical Internet PubMed Software User-Computer Interface Medical Informatics Applications Knowledge Bases Semantics Information Seeking Behavior
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Performance of a Knowledge-Based Model for Optimization of Volumetric Modulated Arc Therapy Plans for Single and Bilateral Breast Irradiation.

PloS one Dec 21, 2015
PURPOSE: To evaluate the performance of a model-based optimisation process for volumetric modulated arc therapy, VMAT, applied to whole breast irradiation.
Models, Biological Humans Knowledge Bases Female Breast Radiotherapy, Intensity-Modulated
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Exchanging expertise and constructing boundaries: The development of a transnational knowledge network around heroin-assisted treatment.

The International journal on drug policy Dec 17, 2015
Over the last 20 years, supervised injectable and inhalable heroin prescribing has been developed, tested and in some cases introduced as a second line treatment for limited groups of entrenched heroin users in a number of European countries and Cana...
Heroin Dependence International Cooperation Stakeholder Participation Interdisciplinary Communication Drug Users Heroin Cooperative Behavior Behavior, Addictive Evidence-Based Medicine Administration, Inhalation Public Opinion Injections, Intravenous Analgesics, Opioid Knowledge Bases Qualitative Research Treatment Outcome Humans
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canSAR: an updated cancer research and drug discovery knowledgebase.

Nucleic acids research Dec 15, 2015
canSAR (http://cansar.icr.ac.uk) is a publicly available, multidisciplinary, cancer-focused knowledgebase developed to support cancer translational research and drug discovery. canSAR integrates genomic, protein, pharmacological, drug and chemical da...
Humans Animals Neoplasms Clinical Trials as Topic Neoplasm Proteins Gene Expression Knowledge Bases Drug Discovery Antineoplastic Agents Cell Line, Tumor
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EHR based Genetic Testing Knowledge Base (iGTKB) Development.

BMC medical informatics and decision making Nov 25, 2015
BACKGROUND: The gap between a large growing number of genetic tests and a suboptimal clinical workflow of incorporating these tests into regular clinical practice poses barriers to effective reliance on advanced genetic technologies to improve qualit...
Humans Electronic Health Records Knowledge Bases Genetic Testing Program Development
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Lynx: a knowledge base and an analytical workbench for integrative medicine.

Nucleic acids research Nov 20, 2015
Lynx (http://lynx.ci.uchicago.edu) is a web-based database and a knowledge extraction engine. It supports annotation and analysis of high-throughput experimental data and generation of weighted hypotheses regarding genes and molecular mechanisms cont...
Data Mining Molecular Sequence Annotation Genes Gene Regulatory Networks Databases, Genetic Knowledge Bases Humans Integrative Medicine Phenotype
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PCOSKB: A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome.

Nucleic acids research Nov 17, 2015
Polycystic ovary syndrome (PCOS) is one of the major causes of female subfertility worldwide and ≈ 7-10% of women in reproductive age are affected by it. The affected individuals exhibit varying types and levels of comorbid conditions, along with the...
Biochemical Phenomena Female Comorbidity Databases, Chemical Mutation Gene Regulatory Networks Humans Protein Conformation Polymorphism, Single Nucleotide Knowledge Bases Databases, Factual Gene Ontology Polycystic Ovary Syndrome
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Knowledge-based iterative model reconstruction: comparative image quality and radiation dose with a pediatric computed tomography phantom.

Pediatric radiology Nov 6, 2015
BACKGROUND: CT of pediatric phantoms can provide useful guidance to the optimization of knowledge-based iterative reconstruction CT.
Humans Machine Learning Female Reproducibility of Results Radiographic Image Enhancement Computer Simulation Tomography, X-Ray Computed Models, Statistical Radiation Exposure Knowledge Bases Subtraction Technique Radiation Protection Radiation Dosage Sensitivity and Specificity Phantoms, Imaging Male Child, Preschool
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