AIMC Topic: Large Language Models

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Collaborative large language models for automated data extraction in living systematic reviews.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Data extraction from the published literature is the most laborious step in conducting living systematic reviews (LSRs). We aim to build a generalizable, automated data extraction workflow leveraging large language models (LLMs) that mimic...

Improving large language model applications in biomedicine with retrieval-augmented generation: a systematic review, meta-analysis, and clinical development guidelines.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: The objectives of this study are to synthesize findings from recent research of retrieval-augmented generation (RAG) and large language models (LLMs) in biomedicine and provide clinical development guidelines to improve effectiveness.

The use of large language models to enhance cancer clinical trial educational materials.

JNCI cancer spectrum
BACKGROUND: Adequate patient awareness and understanding of cancer clinical trials is essential for trial recruitment, informed decision making, and protocol adherence. Although large language models (LLMs) have shown promise for patient education, t...

[Evaluating the accuracy of large language models in answering mammography screening questions in Italian and English: a study based on the Eusobi guidelines.].

Recenti progressi in medicina
INTRODUCTION: Artificial intelligence (AI) is transforming various aspects of everyday life, including healthcare, through large language models (LLMs) like ChatGPT, Gemini, and Copilot. These systems are increasingly used to disseminate medical info...

RAMIE: retrieval-augmented multi-task information extraction with large language models on dietary supplements.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: To develop an advanced multi-task large language model (LLM) framework for extracting diverse types of information about dietary supplements (DSs) from clinical records.

Utility of word embeddings from large language models in medical diagnosis.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: This study evaluates the utility of word embeddings, generated by large language models (LLMs), for medical diagnosis by comparing the semantic proximity of symptoms to their eponymic disease embedding ("eponymic condition") and the mean o...

A dataset and benchmark for hospital course summarization with adapted large language models.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVE: Brief hospital course (BHC) summaries are clinical documents that summarize a patient's hospital stay. While large language models (LLMs) depict remarkable capabilities in automating real-world tasks, their capabilities for healthcare appl...

Analysis of eligibility criteria clusters based on large language models for clinical trial design.

Journal of the American Medical Informatics Association : JAMIA
OBJECTIVES: Clinical trials (CTs) are essential for improving patient care by evaluating new treatments' safety and efficacy. A key component in CT protocols is the study population defined by the eligibility criteria. This study aims to evaluate the...

ESCARGOT: an AI agent leveraging large language models, dynamic graph of thoughts, and biomedical knowledge graphs for enhanced reasoning.

Bioinformatics (Oxford, England)
MOTIVATION: LLMs like GPT-4, despite their advancements, often produce hallucinations and struggle with integrating external knowledge effectively. While Retrieval-Augmented Generation (RAG) attempts to address this by incorporating external informat...

Assessing Completeness of Clinical Histories Accompanying Imaging Orders Using Adapted Open-Source and Closed-Source Large Language Models.

Radiology
Background Incomplete clinical histories are a well-known problem in radiology. Previous dedicated quality improvement efforts focusing on reproducible assessments of the completeness of free-text clinical histories have relied on tedious manual anal...