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Limit of Detection

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Quantitative Rapid Magnetic Immunoassay for Sensitive Toxin Detection in Food: Non-Covalent Functionalization of Nanolabels vs. Covalent Immobilization.

Toxins
In this study, we present a novel and ultrasensitive magnetic lateral flow immunoassay (LFIA) tailored for the precise detection of zearalenone, a mycotoxin with significant implications for human and animal health. A versatile and straightforward me...

Handheld Biosensor System Based on a Gradient Grating Period Guided-Mode Resonance Device.

Biosensors
Handheld biosensors have attracted substantial attention for numerous applications, including disease diagnosis, drug dosage monitoring, and environmental sensing. This study presents a novel handheld biosensor based on a gradient grating period guid...

Microextraction by packed sorbent of N-nitrosamines from Losartan tablets using a high-throughput robot platform followed by liquid chromatography-tandem mass spectrometry.

Journal of separation science
The development of a fast, cost-effective, and efficient microextraction by packed sorbent setup was achieved by combining affordable laboratory-repackable devices of microextraction with a high-throughput cartesian robot. This setup was evaluated fo...

A deep learning-enabled smartphone platform for rapid and sensitive colorimetric detection of dimethoate pesticide.

Analytical and bioanalytical chemistry
A novel deep learning-enabled smartphone platform is developed to assist a colorimetric aptamer biosensor for fast and highly sensitive detection of dimethoate. The colorimetric determination of dimethoate is based on the specific binding of dimethoa...

Harnessing Small-Molecule Analyte Detection in Complex Media: Combining Molecularly Imprinted Polymers, Electrolytic Transistors, and Machine Learning.

ACS applied materials & interfaces
Small-molecule analyte detection is key for improving quality of life, particularly in health monitoring through the early detection of diseases. However, detecting specific markers in complex multicomponent media using devices compatible with point-...

Mn-Triggered Swing-Arm Robot Strategy Using Anemone-Like Thi@AuPd@Cu-MOFs as Signaling Probes for the Detection of T-2 Toxin.

Analytical chemistry
Herein, we synthesized anemone-like copper-based metal-organic frameworks (MOFs) loaded with gold-palladium nanoparticles (AuPd@Cu-MOFs) and polyethylenimine-reduced graphene oxide/gold-silver nanosheet composites (PEI-rGO/AuAg NSs) for the first tim...

Deep Learning-Assisted Intelligent Artificial Vision Platform Based on Dual-Luminescence Eu(III)-Functionalized HOF for the Diagnosis of Breast and Ovarian Cancer.

Analytical chemistry
Developing an advanced analytical method to detect spermine (Spm) and -acetylneuraminic acid (NANA), the biomarkers of breast and ovarian cancers, respectively, is critical for the early diagnosis of the two cancers, which is very meaningful for wome...

Improving the detection accuracy of the dual SERS aptasensor system with uncontrollable SERS "hot spot" using machine learning tools.

Analytica chimica acta
BACKGROUND: Simultaneous detection of food contaminants is crucial in addressing the collective health hazards arising from the presence of multiple contaminants. However, traditional multi-competitive surface-enhanced Raman scattering (SERS) aptasen...

Development of surface molecular-imprinted electrochemical sensor for palmitic acid with machine learning assistance.

Talanta
Palmitic acid (PA) is a kind of saturated high fatty acid, which is involved in physiological safety and food quality. A surface molecularly imprinted polymer (MIP) electrochemical sensor was prepared on MXene surface using dopamine (DA) as functiona...

Deep Learning-Assisted Colorimetric/Electrical Dual-Sensing System for Ultrafast Detection of Hydrogen Sulfide.

ACS sensors
This study presents a colorimetric/electrical dual-sensing system (CEDS) for low-power, high-precision, adaptable, and real-time detection of hydrogen sulfide (HS) gas. The lead acetate/poly(vinyl alcohol) (Pb(Ac)/PVA) nanofiber film was transferred ...