Artificial intelligence, specifically machine learning, has found numerous applications in computer-aided diagnostics, monitoring and management of neurodegenerative movement disorders of parkinsonian type. These tasks are not trivial due to high int...
OBJECTIVE: The objective is to develop and validate a predictive model for 15-month mortality using a random sample of community-dwelling Medicare beneficiaries.
Journal of biopharmaceutical statistics
Jul 16, 2019
Personalized medicine has received increasing attentions among scientific communities in recent years. Because patients often have heterogenous responses to treatments, discovering individualized treatment rules (ITR) is an important component of pre...
Journal of molecular graphics & modelling
Jul 15, 2019
Membrane proteins, the most important drug targets, account for around 30% of total proteins encoded by the genome of living organisms. An important role of these proteins is to bind adenosine triphosphate (ATP), facilitating crucial biological proce...
Feature selection is an important initial step of exploratory analysis in biomedical studies. Its main objective is to eliminate the covariates that are uncorrelated with the outcome. For highly correlated covariates, traditional feature selection me...
Neural networks : the official journal of the International Neural Network Society
Jul 15, 2019
The Lyapunov-Krasovskii functional approach is an important and effective delay-dependent stability analysis method for integer order system. However, it cannot be applied directly to fractional-order (FO) systems. To obtain delay-dependent stability...
Neural networks : the official journal of the International Neural Network Society
Jul 15, 2019
Recurrent neural networks (RNN) model time series by feeding back the representation from the previous time instant as an input for the current instant along with exogenous inputs. Two main shortcomings of RNN are - 1. The problem of vanishing gradie...
Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for high-risk acute leukemia (AL), some patients still relapse. Since patients simultaneously have many prognostic factors, difficulties are associated with...
The United States of America is fighting against one of its worst-ever drug crises. Over 900 people a week die from opioid- or heroin-related overdoses, while millions more suffer from opioid prescription addiction. Recently, drug overdoses caused by...
Protein engineering through machine-learning-guided directed evolution enables the optimization of protein functions. Machine-learning approaches predict how sequence maps to function in a data-driven manner without requiring a detailed model of the ...
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