Mathematical biosciences and engineering : MBE
Feb 20, 2019
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
Though the advent of long-read sequencing technologies has led to a leap in contiguity of de novo genome assemblies, current reference genomes of higher organisms still do not provide unbroken sequences of complete chromosomes. Despite reads in exces...
Mathematical biosciences and engineering : MBE
Feb 19, 2019
The Hough transform has been widely used in image analysis and digital image processing due to its capability of transforming image space detection to parameter space accumulation. In this paper, we propose a novel Angle-Aided Circle Detection (AACD)...
Journal of the American Heart Association
Feb 19, 2019
Background An angiography-based supervised machine learning ( ML ) algorithm was developed to classify lesions as having fractional flow reserve ≤0.80 versus >0.80. Methods and Results With a 4:1 ratio, 1501 patients with 1501 intermediate lesions we...
Mathematical biosciences and engineering : MBE
Feb 18, 2019
Particle swarm optimizer was proposed in 1995, and since then, it has become an extremely popular swarm intelligent algorithm with widespread applications. Many modified versions of it have been developed, in which, comprehensive learning particle sw...
American journal of respiratory and critical care medicine
Feb 15, 2019
A paradigm shift brought by the recognition that childhood asthma is an aggregated diagnosis that comprises several different endotypes underpinned by different pathophysiology, coupled with advances in understanding potentially important causal mech...
MOTIVATION: N4-methylcytosine (4mC), an important epigenetic modification formed by the action of specific methyltransferases, plays an essential role in DNA repair, expression and replication. The accurate identification of 4mC sites aids in-depth r...
Artificial intelligence (AI), particularly deep learning algorithms, is gaining extensive attention for its excellent performance in image-recognition tasks. They can automatically make a quantitative assessment of complex medical image characteristi...
Coral reefs worldwide face unprecedented cumulative anthropogenic effects of interacting local human pressures, global climate change and distal social processes. Reefs are also bound by the natural biophysical environment within which they exist. In...
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