Herein, a novel tri-functional Mn-doped covalent organic polymer nanozyme (Mn-COP) with peroxidase-like, oxidase-like, and laccase-like activities was synthesized. The strong reducing power of flavonoids inhibited the tri-enzymes-like activity from M...
Biochemical and biophysical research communications
Oct 21, 2025
BACKGROUND: Bicuspid aortic valve (BAV), the most common congenital heart defect, is strongly predisposed to early calcification, yet the molecular drivers remain poorly defined. This study aims to identify the functional role of transient receptor p...
Preserving proteome integrity is crucial for maintaining cell viability across all kingdoms of life. The bacterial caseinolytic protease (ClpP) plays a critical role in maintaining protein homeostasis by degrading misfolded or damaged proteins within...
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and its most common application, MALD-MS imaging (MSI), are widely used techniques in the analysis of intact biomolecules. In the context of pharmaceutical research, MALDI-MSI i...
The ability to pinpoint and predict sites of metabolism (SoMs) is essential for designing and optimizing effective and safe bioactive small molecules. However, the number of molecules with annotated SoMs is limited, hindering the advancement of data-...
Integrating artificial intelligence into psychological research represents a significant direction in contemporary psychology. Utilizing supervised and unsupervised machine learning techniques can further aid in understanding the nonlinear relationsh...
We systematically evaluated three key determinants affecting prediction accuracy and the algorithm performance differences based on fifteen state-of-the-art GP methods, and found LSTM suitable for capturing additive and epistatic effects. Genomic pre...
Traditional track and field education relies heavily on subjective assessment and manual feedback systems, creating critical barriers to personalized instruction in large-scale educational settings. This study presents a novel machine learning framew...
The Internet of Things (IoT) has emerged as a powerful technology in various fields, including healthcare, assisting the elderly and disabled individuals. Solution-based IoT is widely utilized in healthcare support in diverse aspects of their daily l...
Increasing water scarcity and climate variability have intensified the need for precise agricultural irrigation management. Accurate estimation of crop coefficients (Kc) is critical for determining crop water requirements, especially in arid and semi...
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