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A novel predictive model and therapeutic potential of quercetin derivatives in chronic kidney disease progression.

Biochemical pharmacology
Chronic kidney disease (CKD) remains a pressing global health issue with limited therapeutic options. The loss of nephrons is a crucial pathological change driving CKD progression, influenced by diverse programmed cell death (PCD) pathways, yet the p...

Causal Discovery Analysis Reveals Insights into Psychosis Proneness, Brain Function, and Environmental Factors among Young Individuals.

Psychiatry research. Neuroimaging
Experiencing mild symptoms of psychosis, like delusions and hallucinations, occurs sometimes in general, nonclinical populations, often termed psychosis proneness (PP), potentially part of the psychosis continuum. Understanding the neural and environ...

Simulating workload reduction with an AI-based prostate cancer detection pathway using a prediction uncertainty metric.

European radiology
OBJECTIVES: This study compared two uncertainty quantification (UQ) metrics to rule out prostate MRI scans with a high-confidence artificial intelligence (AI) prediction and investigated the resulting potential radiologist's workload reduction in a c...

Automated transcatheter heart valve 4DCT-based deformation assessment throughout the cardiac cycle: Towards enhanced long-term durability.

International journal of medical informatics
BACKGROUND: Transcatheter heart valve (THV) durability is a critical concern, and its deformation may influence long-term performance. Current assessments rely on CT-based single-phase measurements and require a tedious analysis process, potentially ...

Current utilization and impact of AI LVO detection tools in acute stroke triage: a multicenter survey analysis.

Neurological research
BACKGROUND: Artificial intelligence (AI) tools for large vessel occlusion (LVO) detection are increasingly used in acute stroke triage to expedite diagnosis and intervention. However, variability in access and workflow integration limits their potent...

Preferences for Telephone Cancer Information and Support in People with Cancer and Carers: Attribute and Level Selection for a Discrete Choice Experiment.

The patient
BACKGROUND AND OBJECTIVE: Telephone cancer information and support services (CISS) deliver essential evidence-based resources for people living with cancer. This research aimed to describe how attributes and levels were developed for a future discret...

HIV Prevention and Treatment Information from Four Artificial Intelligence Platforms: A Thematic Analysis.

AIDS and behavior
Health information is highly accessible with the prominence of artificial intelligence (AI) platforms, such as Chat Generative Pre-Trained Transformer (ChatGPT). Within the context of human immunodeficiency virus (HIV), it is paramount to understand ...

Physics-informed neural networks for denoising high b-value diffusion-weighted images.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Diffusion-weighted imaging (DWI) is widely applied in tumor diagnosis by measuring the diffusion of water molecules. To increase the sensitivity to tumor identification, faithful high b-value DWI images are expected by setting a stronger strength of ...

Spatiotemporal dynamics of reading Kana (syllabograms) and Kanji (morphograms).

NeuroImage
Reading engages complex neural networks integrating visual, phonological, and semantic information. The dual-stream model posits ventral and dorsal pathways for lexical and sublexical processing in the left hemisphere and is well-supported in alphabe...