The Journal of neuroscience : the official journal of the Society for Neuroscience
Oct 8, 2025
In temporal lobe epilepsy, interictal spikes (IS)-hyper-synchronous bursts of network activity-occur at high rates in between seizures. We sought to understand the influence of IS on working memory by recording hippocampal local field potentials from...
Behavioral neuroscience research often requires substantial financial investment in specialized equipment and software, creating barriers for new investigators and limiting the flexibility of established laboratories. This study explores how 3D print...
Working memory (WM) is a core cognitive mechanism necessary for adaptive behavior. In the last few decades, scientists have studied WM using rodent models through traditional and time-consuming approaches, such as the Radial Arm Maze and the T-Maze. ...
The Morris Water Maze (MWM) is a widely used behavioral test to assess the spatial learning and memory of animals, particularly valuable in studying neurodegenerative disorders such as Alzheimer's disease. Traditional methods for analyzing MWM experi...
Assessment of spatial learning abilities is central to behavioral neuroscience and a useful tool for animal model validation and drug development. However, biases introduced by the apparatus, environment, or experimentalist represent a critical chall...
Neural networks : the official journal of the International Neural Network Society
Mar 30, 2023
Learning to navigate a complex environment is not a difficult task for a mammal. For example, finding the correct way to exit a maze following a sequence of cues, does not need a long training session. Just a single or a few runs through a new enviro...
Neural networks : the official journal of the International Neural Network Society
Dec 8, 2020
Modular Reinforcement Learning decomposes a monolithic task into several tasks with sub-goals and learns each one in parallel to solve the original problem. Such learning patterns can be traced in the brains of animals. Recent evidence in neuroscienc...
The Morris water maze test (MWM) is a useful tool to evaluate rodents' spatial learning and memory, but the outcome is susceptible to various experimental conditions. Thigmotaxis is a commonly observed behavioral pattern which is thought to be relate...
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients rec...
Neural networks : the official journal of the International Neural Network Society
Dec 7, 2016
Electrophysiological studies in animals may provide a great insight into developing brain-like models of spatial cognition for robots. These studies suggest that the spatial ability of animals requires proper functioning of the hippocampus and the en...
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