Uncovering the molecular context of dysregulated metabolites is crucial to understand pathogenic pathways. However, their system-level analysis has been limited owing to challenges in global metabolite identification. Most metabolite features detecte...
Identifying the molecular targets for the beneficial effects of active small-molecule compounds simultaneously is an important and currently unmet challenge. In this study, we firstly proposed network analysis by integrating data from network pharmac...
Toxicological sciences : an official journal of the Society of Toxicology
Jan 18, 2016
Current studies that evaluate toxicity based on metabolomics have primarily focused on the screening of biomarkers while largely neglecting further verification and biomarker applications. For this reason, we used drug-induced hepatotoxicity as an ex...
Proceedings of the National Academy of Sciences of the United States of America
Sep 21, 2015
Metabolites provide a direct functional signature of cellular state. Untargeted metabolomics experiments usually rely on tandem MS to identify the thousands of compounds in a biological sample. Today, the vast majority of metabolites remain unknown. ...
Nonsteroidal anti-inflammatory drugs are the most used anti-inflammatory medicines in the world. Side effects still occur, however, and some inflammatory pathologies lack efficient treatment. Cyclooxygenase and lipoxygenase pathways are of utmost imp...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dec 15, 2025
Cryptogenic stroke represents 25%-40% of ischemic strokes, with many cases harboring unrecognized large artery atherosclerosis (LAA) requiring specific secondary prevention. In this multicenter pilot study, we developed a metabolomics-based machine l...
Rising atmospheric CO2 and intensified drought are reshaping nutrient dynamics in C3 plants, with implications for ecosystem function and food security. To investigate how these stressors jointly affect nutrient homeostasis, we examined Brachypodium ...
Compound annotation, including the unveiling of dark matter in the metabolomics study represents a pivotal undertaking within the metabolomics field, serving as the linchpin for unraveling the identities and attributes of chemical entities. This narr...
Although egg flavour influences consumer preference and satisfaction, the features governing the flavour profiles have been poorly studied. This study investigated the volatile compounds and lipid profiles of different poultry egg yolks (chicken, duc...
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