AIMC Topic: Mice

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Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests.

Advanced materials (Deerfield Beach, Fla.)
Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot ...

Systematic Analysis and Prediction of In Situ Cross Talk of O-GlcNAcylation and Phosphorylation.

BioMed research international
Reversible posttranslational modification (PTM) plays a very important role in biological process by changing properties of proteins. As many proteins are multiply modified by PTMs, cross talk of PTMs is becoming an intriguing topic and draws much at...

The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Research in veterinary science
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...

Alkaline phosphatase determines polyphosphate-induced mineralization in a cell-type independent manner.

Journal of bone and mineral metabolism
Polyphosphate [Poly(P)] has positive effects on osteoblast mineralization; however, the underlying mechanism remains unclear. In addition, it is unknown whether Poly(P) promotes mineralization in soft tissues. We investigated this by using various ce...

Firing rate dynamics in recurrent spiking neural networks with intrinsic and network heterogeneity.

Journal of computational neuroscience
Heterogeneity of neural attributes has recently gained a lot of attention and is increasing recognized as a crucial feature in neural processing. Despite its importance, this physiological feature has traditionally been neglected in theoretical studi...

Effect of earthworm active protein on fibroblast proliferation and its mechanism.

Pharmaceutical biology
CONTEXT: Earthworms have been used as a traditional medicine in China from thousands of years. In recent years, research has demonstrated that earthworm extracts might promote wound healing; however, its mechanism is still unknown.

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification.

Immunogenetics
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound peptide is then presented ...

Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.

Pharmaceutical research
PURPOSE: Mouse efficacy studies are a critical hurdle to advance translational research of potential therapeutic compounds for many diseases. Although mouse liver microsomal (MLM) stability studies are not a perfect surrogate for in vivo studies of m...

Characterization and machine learning prediction of allele-specific DNA methylation.

Genomics
A large collection of Single Nucleotide Polymorphisms (SNPs) has been identified in the human genome. Currently, the epigenetic influences of SNPs on their neighboring CpG sites remain elusive. A growing body of evidence suggests that locus-specific ...

PathwaysWeb: a gene pathways API with directional interactions, expanded gene ontology, and versioning.

Bioinformatics (Oxford, England)
UNLABELLED: PathwaysWeb is a resource-based, well-documented web system that provides publicly available information on genes, biological pathways, Gene Ontology (GO) terms, gene-gene interaction networks (importantly, with the directionality of inte...