International journal for numerical methods in biomedical engineering
Oct 29, 2024
Experimental studies on the cellular uptake of nanoparticles (NPs), useful for the investigation of NP-based drug delivery systems, are often difficult to interpret due to the large number of parameters that can contribute to the phenomenon. It is th...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Oct 28, 2024
Plasma protein binding (PPB) is closely related to pharmacokinetics, pharmacodynamics and drug toxicity. Existing models for predicting PPB often suffer from low prediction accuracy and poor interpretability, especially for high PPB compounds, and ar...
Geobacillus thermoglucosidasius NCIMB 11955 possesses advantages, such as high-temperature tolerance, rapid growth rate, and low contamination risk. Additionally, it features efficient gene editing tools, making it one of the most promising next-gene...
Accurate modeling of methane (CH) and sulfide (HS) production in sewer systems was constrained by insufficient consideration of microbial processes under dynamic environmental conditions. This study introduces a microbial-guided machine learning (ML)...
Mathematical neuroscience investigates how calcium distribution in nerve cells affects the neurological system. The interaction of numerous systems is necessary for the operation of several cellular processes in neuron cells, such as calcium, buffer,...
BACKGROUND: Diffusion distance and diffusivity are known to affect nutrient transport rates, but the probabilistic analysis of these two factors remains vacant. There is a lack of effective tools to evaluate disc nutrient levels.
Aedes mosquitoes, known as vectors of mosquito-borne diseases, pose significant risks to public health and safety. Modeling the population dynamics of Aedes mosquitoes requires comprehensive approaches due to the complex interplay between biological ...
Drug-induced Torsade de Pointes (TdP), a life-threatening polymorphic ventricular tachyarrhythmia, emerges due to the cardiotoxic effects of pharmaceuticals. The need for precise mechanisms and clinical biomarkers to detect this adverse effect presen...
Given the aging populations in advanced countries globally, many pharmaceutical companies have focused on developing central nervous system (CNS) drugs. However, due to the blood-brain barrier, drugs do not easily reach the target area in the brain. ...
Accurate perception of biological tissues (BT) thickness is essential for preliminary evaluation of medical diagnosis and animal nutrition. However, traditional thickness measuring approaches of BT require complex operation, high-cost, and trigger bi...