AIMC Topic: Models, Biological

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Low-dimensional neural ordinary differential equations accounting for inter-individual variability implemented in Monolix and NONMEM.

CPT: pharmacometrics & systems pharmacology
Neural ordinary differential equations (NODEs) are an emerging machine learning (ML) method to model pharmacometric (PMX) data. Combining mechanism-based components to describe "known parts" and neural networks to learn "unknown parts" is a promising...

Artificial intelligence modeling of biomarker-based physiological age: Impact on phase 1 drug-metabolizing enzyme phenotypes.

CPT: pharmacometrics & systems pharmacology
Age and aging are important predictors of health status, disease progression, drug kinetics, and effects. The purpose was to develop ensemble learning-based physiological age (PA) models for evaluating drug metabolism. National Health and Nutrition E...

The influence of neighbor selection on self-organized UAV swarm based on finite perception vision.

Bioinspiration & biomimetics
Recently, vision-based unmanned aerial vehicle (UAV) swarming has emerged as a promising alternative that can overcome the adaptability and scalability limitations of distributed and communication-based UAV swarm systems. While most vision-based cont...

Soft robots and soft bodies: biological insights into the structure and function of fluidic soft robots.

Bioinspiration & biomimetics
Over the last two decades, robotics engineering has witnessed rapid growth in the exploration and development of soft robots. Soft robots are made of deformable materials with mechanical properties or other features that resemble biological structure...

Assessment of fuzzy logic to enhance species distribution modelling of two cryptic wood boring beetle species in Australia.

Scientific reports
Fuzzy logic presents a promising approach for Species Distribution Modelling by generating a value that can be used for comparative purposes termed 'environmental favourability'. In contrast to 'presence probability', 'environmental favourability' re...

Dynamic modelling and predictive position/force control of a plant-inspired growing robot.

Bioinspiration & biomimetics
This paper presents the development and control of a dynamic model for a plant-inspired growing robot, termed the 'vine-robot', using the Euler-Lagrangian method. The unique growth mechanism of the vine-robot enables it to navigate complex environmen...

A comprehensive review on the application of neural network model in microbial fermentation.

Bioresource technology
The development of high-performance strains and the continuous breakthrough of strain screening technology also pose challenges to downstream fermentation optimization and scale-up. Therefore, neural network models are utilized to optimize the fermen...

Exploring the spatial effects influencing the EGFR/ERK pathway dynamics with machine learning surrogate models.

Bio Systems
The fate of cells is regulated by biochemical reactions taking place inside of them, known as intracellular pathways. Cells display a variety of characteristics related to their shape, structure and contained fluid, which influences the diffusion of ...

Prediction of Multi-Pharmacokinetics Property in Multi-Species: Bayesian Neural Network Stacking Model with Uncertainty.

Molecular pharmaceutics
Pharmacokinetic (PK) properties of a drug are vital attributes influencing its therapeutic effectiveness, playing an important role in the drug development process. Focusing on the difficult task of predicting PK parameters, we compiled an extensive ...

Enhancing postural stability in musculoskeletal quadrupedal locomotion through tension feedback for CPG-based controller.

Bioinspiration & biomimetics
A central pattern generator (CPG)-based controller enhances the adaptability of quadrupedal locomotion, for example, by controlling the trunk posture. The conventional CPG-based controllers with attitude control often utilized the posture angle as fe...