AIMC Topic: Models, Biological

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Gait-Event-Based Synchronization Method for Gait Rehabilitation Robots via a Bioinspired Adaptive Oscillator.

IEEE transactions on bio-medical engineering
In the field of gait rehabilitation robotics, achieving human-robot synchronization is very important. In this paper, a novel human-robot synchronization method using gait event information is proposed. This method includes two steps. First, seven ga...

A design concept of parallel elasticity extracted from biological muscles for engineered actuators.

Bioinspiration & biomimetics
Series elastic actuation that takes inspiration from biological muscle-tendon units has been extensively studied and used to address the challenges (e.g. energy efficiency, robustness) existing in purely stiff robots. However, there also exists anoth...

Theoretical and experimental study on a compliant flipper-leg during terrestrial locomotion.

Bioinspiration & biomimetics
An amphibious robot with straight compliant flipper-legs can conquer various amphibious environments. The robot can rotate its flipper-legs and utilize their large deflection to walk on rough terrain, and it can oscillate the straight flipper-legs to...

Recurrent neural network based hybrid model for reconstructing gene regulatory network.

Computational biology and chemistry
One of the exciting problems in systems biology research is to decipher how genome controls the development of complex biological system. The gene regulatory networks (GRNs) help in the identification of regulatory interactions between genes and offe...

DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactions.

BMC medical genomics
BACKGROUND: Genomic variations are associated with the metabolism and the occurrence of adverse reactions of many therapeutic agents. The polymorphisms on over 2000 locations of cytochrome P450 enzymes (CYP) due to many factors such as ethnicity, mut...

Daily changes of individual gait patterns identified by means of support vector machines.

Gait & posture
Despite the common knowledge about the individual character of human gait patterns and about their non-repeatability, little is known about their stability, their interactions and their changes over time. Variations of gait patterns are typically des...

Protein-protein interaction network construction for cancer using a new L1/2-penalized Net-SVM model.

Genetics and molecular research : GMR
Identifying biomarker genes and characterizing interaction pathways with high-dimensional and low-sample size microarray data is a major challenge in computational biology. In this field, the construction of protein-protein interaction (PPI) networks...

Control of Redundant Kinematic Degrees of Freedom in a Closed-Loop Brain-Machine Interface.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Brain-machine interface (BMI) systems use signals acquired from the brain to directly control the movement of an actuator, such as a computer cursor or a robotic arm, with the goal of restoring motor function lost due to injury or disease of the nerv...

COMODI: an ontology to characterise differences in versions of computational models in biology.

Journal of biomedical semantics
BACKGROUND: Open model repositories provide ready-to-reuse computational models of biological systems. Models within those repositories evolve over time, leading to different model versions. Taken together, the underlying changes reflect a model's pr...

Confirming an integrated pathology of diabetes and its complications by molecular biomarker-target network analysis.

Molecular medicine reports
Despite ongoing research into diabetes and its complications, the underlying molecular associations remain to be elucidated. The systematic identification of molecular interactions in associated diseases may be approached using a network analysis str...