AIMC Topic: Models, Genetic

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Prediction of Genotype Positivity in Patients With Hypertrophic Cardiomyopathy Using Machine Learning.

Circulation. Genomic and precision medicine Apr 23, 2021
BACKGROUND: Genetic testing can determine family screening strategies and has prognostic and diagnostic value in hypertrophic cardiomyopathy (HCM). However, it can also pose a significant psychosocial burden. Conventional scoring systems offer modest...
Female Risk Factors Aged Humans Machine Learning Risk Assessment Genotype Models, Genetic Adult Male Middle Aged Predictive Value of Tests Genetic Testing Cardiomyopathy, Hypertrophic
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CBCR: A Curriculum Based Strategy For Chromosome Reconstruction.

International journal of molecular sciences Apr 16, 2021
In this paper, we introduce a novel algorithm that aims to estimate chromosomes' structure from their Hi-C contact data, called Curriculum Based Chromosome Reconstruction (CBCR). Specifically, our method performs this three dimensional reconstruction...
Chromosome Mapping Humans Machine Learning Models, Genetic Chromosomes
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A convolutional neural network for the prediction and forward design of ribozyme-based gene-control elements.

eLife Apr 16, 2021
Ribozyme switches are a class of RNA-encoded genetic switch that support conditional regulation of gene expression across diverse organisms. An improved elucidation of the relationships between sequence, structure, and activity can improve our capaci...
Nucleic Acid Conformation Saccharomyces cerevisiae RNA, Catalytic Aptamers, Nucleotide High-Throughput Nucleotide Sequencing Sequence Analysis, RNA Gene Expression Regulation Neural Networks, Computer Models, Genetic Base Sequence Machine Learning Escherichia coli Computer-Aided Design Structure-Activity Relationship Ligands
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Automatic Search-and-Replace From Examples With Coevolutionary Genetic Programming.

IEEE transactions on cybernetics Apr 15, 2021
We describe the design and implementation of a system for executing search-and-replace text processing tasks automatically, based only on examples of the desired behavior. The examples consist of pairs describing the original string and the desired m...
Models, Genetic Machine Learning Evolution, Molecular Software Data Mining Algorithms
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Ridge regression and its applications in genetic studies.

PloS one Apr 8, 2021
With the advancement of technology, analysis of large-scale data of gene expression is feasible and has become very popular in the era of machine learning. This paper develops an improved ridge approach for the genome regression modeling. When multic...
Models, Genetic Regression Analysis Machine Learning Computer Simulation
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A Fast Linear Neighborhood Similarity-Based Network Link Inference Method to Predict MicroRNA-Disease Associations.

IEEE/ACM transactions on computational biology and bioinformatics Apr 6, 2021
Increasing evidences revealed that microRNAs (miRNAs) play critical roles in important biological processes. The identification of disease-related miRNAs is critical to understand the molecular mechanisms of human diseases. Most existing computationa...
MicroRNAs Linear Models Genetic Predisposition to Disease Computational Biology Models, Genetic Humans Machine Learning
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Harnessing machine learning to guide phylogenetic-tree search algorithms.

Nature communications Mar 31, 2021
Inferring a phylogenetic tree is a fundamental challenge in evolutionary studies. Current paradigms for phylogenetic tree reconstruction rely on performing costly likelihood optimizations. With the aim of making tree inference feasible for problems i...
Evolution, Molecular Machine Learning Humans Phylogeny Databases, Protein Models, Genetic Databases, Genetic Algorithms Animals
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Full-length ribosome density prediction by a multi-input and multi-output model.

PLoS computational biology Mar 26, 2021
Translation elongation is regulated by a series of complicated mechanisms in both prokaryotes and eukaryotes. Although recent advance in ribosome profiling techniques has enabled one to capture the genome-wide ribosome footprints along transcripts at...
Computational Biology Ribosomes RNA, Messenger Peptide Chain Elongation, Translational Deep Learning Escherichia coli Models, Genetic Saccharomyces cerevisiae Codon
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Trivial and nontrivial error sources account for misidentification of protein partners in mutual information approaches.

Scientific reports Mar 25, 2021
The problem of finding the correct set of partners for a given pair of interacting protein families based on multi-sequence alignments (MSAs) has received great attention over the years. Recently, the native contacts of two interacting proteins were ...
Sequence Alignment Machine Learning Biological Coevolution Models, Genetic Evolution, Molecular Proteins
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Virtual Transcriptomics: Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging.

Arteriosclerosis, thrombosis, and vascular biology Mar 11, 2021
[Figure: see text].
Artificial Intelligence Phenotype Female Aged Male Gene Expression Profiling Humans Coronary Artery Disease Feasibility Studies Predictive Value of Tests Coronary Vessels Transcriptome Coronary Angiography Plaque, Atherosclerotic Pilot Projects Radiographic Image Interpretation, Computer-Assisted Oligonucleotide Array Sequence Analysis Models, Genetic Computed Tomography Angiography
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