AIMC Topic: Molecular Targeted Therapy

Clear Filters Showing 51 to 60 of 77 articles

Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I.

Tuberculosis (Edinburgh, Scotland) Jan 20, 2017
There is a shortage of compounds that are directed towards new targets apart from those targeted by the FDA approved drugs used against Mycobacterium tuberculosis. Topoisomerase I (Mttopo I) is an essential mycobacterial enzyme and a promising target...
Machine Learning Molecular Docking Simulation Computer-Aided Design Drug Design Humans Antitubercular Agents Tuberculosis Mycobacterium tuberculosis Molecular Targeted Therapy Dose-Response Relationship, Drug Structure-Activity Relationship Bayes Theorem Topoisomerase I Inhibitors Protein Conformation Mycobacterium smegmatis DNA Topoisomerases, Type I
View on PubMed DOI

Preparation of arginine-glycine-aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization.

International journal of nanomedicine Dec 30, 2016
Neovascularization (NV) of the cornea can disrupt visual function, causing ocular diseases, including blindness. Therefore, treatment of corneal NV has a high public health impact. Epigalloccatechin-3-gallate (EGCG), presenting antiangiogenesis effec...
Eye Burns Oligopeptides Integrin alphaVbeta3 Corneal Neovascularization Cell Survival Burns, Chemical Human Umbilical Vein Endothelial Cells Catechin Molecular Targeted Therapy Ophthalmic Solutions Hyaluronic Acid Angiogenesis Inhibitors Humans Disease Models, Animal Animals Mice, Inbred C57BL Nanoparticles
View on PubMed DOI

Linking rare and common disease: mapping clinical disease-phenotypes to ontologies in therapeutic target validation.

Journal of biomedical semantics Mar 23, 2016
BACKGROUND: The Centre for Therapeutic Target Validation (CTTV - https://www.targetvalidation.org/) was established to generate therapeutic target evidence from genome-scale experiments and analyses. CTTV aims to support the validity of therapeutic t...
Molecular Targeted Therapy Rare Diseases Humans Phenotype Databases, Factual Data Mining Biological Ontologies Inflammatory Bowel Diseases Reproducibility of Results
View on PubMed DOI

A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.

Journal of bioinformatics and computational biology Oct 27, 2015
The blood-brain barrier (BBB), a highly selective barrier between central nervous system (CNS) and the blood stream, restricts and regulates the penetration of compounds from the blood into the brain. Drugs that affect the CNS interact with the BBB p...
Permeability Plants, Medicinal Molecular Targeted Therapy ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Evaluation, Preclinical Humans Central Nervous System Agents Algorithms Reproducibility of Results Support Vector Machine Medicine, Chinese Traditional Blood-Brain Barrier Models, Theoretical
View on PubMed DOI

Nanorobots: Changing Trends in Cancer Therapy.

The journal of contemporary dental practice Sep 1, 2015
Humans Nanostructures Neoplasms Molecular Targeted Therapy Nanomedicine Biotechnology Robotics DNA
View on PubMed

Exploring the relationship between hub proteins and drug targets based on GO and intrinsic disorder.

Computational biology and chemistry Mar 23, 2015
Protein-protein interactions (PPIs) play essential roles in many biological processes. In protein-protein interaction networks, hubs involve in numbers of PPIs and may constitute an important source of drug targets. The intrinsic disorder proteins (I...
Humans Drug Discovery Protein Interaction Maps Databases, Protein Molecular Targeted Therapy Computational Biology Gene Ontology Support Vector Machine Protein Interaction Mapping Proteins
View on PubMed DOI

Active-learning strategies in computer-assisted drug discovery.

Drug discovery today Dec 9, 2014
High-throughput compound screening is time and resource consuming, and considerable effort is invested into screening compound libraries, profiling, and selecting the most promising candidates for further testing. Active-learning methods assist the s...
Molecular Structure Pharmaceutical Preparations Supervised Machine Learning Databases, Pharmaceutical Databases, Chemical Molecular Targeted Therapy Computer-Aided Design Drug Discovery Computational Biology Humans Structure-Activity Relationship Algorithms Animals
View on PubMed DOI

Medical management of pancreatic cancer: from personalization to broadening treatment strategies.

Cancer treatment reviews Jul 1, 2025
Pancreatic ductal adenocarcinoma (PDAC) is one of the most heterogeneous and deadly cancers. This review examines recently implemented strategies to integrate predictive tools and targeted therapies to improve treatments personalization and patient o...
Carcinoma, Pancreatic Ductal Molecular Targeted Therapy Humans Precision Medicine Pancreatic Neoplasms
View on PubMed DOI

Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis.

Journal of dermatological science Jul 1, 2025
BACKGROUND: The development of medical treatments has traditionally relied on researchers leveraging scientific knowledge to hypothesize disease mechanisms and identify therapeutic agents. However, the depletion of novel therapeutic targets has becom...
Drug Discovery Big Data Interleukin-17 Mice Machine Learning Humans Tumor Necrosis Factor-alpha Animals Disease Models, Animal Psoriasis Skin Imiquimod Molecular Targeted Therapy Dopamine Agonists Receptors, Dopamine D2
View on PubMed DOI

Editorial: New Target for Skin Cancer.

Experimental dermatology Jun 1, 2025
Skin cancer encompasses a diverse spectrum of malignancies with increasing global incidence and persistent clinical challenges. Despite advances in therapies such as immune checkpoint inhibitors and targeted agents, many patients-especially those wit...
Humans Molecular Targeted Therapy Skin Neoplasms Tumor Microenvironment
View on PubMed DOI
Popular Topics
Recent Journals