AIMC Topic: Multifactor Dimensionality Reduction
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Novel Online Dimensionality Reduction Method with Improved Topology Representing and Radial Basis Function Networks.
PloS one
Jul 10, 2015
This paper presents improvements to the conventional Topology Representing Network to build more appropriate topology relationships. Based on this improved Topology Representing Network, we propose a novel method for online dimensionality reduction t...
SPECTRUS: A Dimensionality Reduction Approach for Identifying Dynamical Domains in Protein Complexes from Limited Structural Datasets.
Structure (London, England : 1993)
Jul 9, 2015
Identifying dynamical, quasi-rigid domains in proteins provides a powerful means for characterizing functionally oriented structural changes via a parsimonious set of degrees of freedom. In fact, the relative displacements of few dynamical domains us...
An efficiency analysis of high-order combinations of gene-gene interactions using multifactor-dimensionality reduction.
BMC genomics
Jul 1, 2015
BACKGROUND: Multifactor dimensionality reduction (MDR) is widely used to analyze interactions of genes to determine the complex relationship between diseases and polymorphisms in humans. However, the astronomical number of high-order combinations mak...
A roadmap to multifactor dimensionality reduction methods.
Briefings in bioinformatics
Jun 24, 2015
Complex diseases are defined to be determined by multiple genetic and environmental factors alone as well as in interactions. To analyze interactions in genetic data, many statistical methods have been suggested, with most of them relying on statisti...
Multifactor dimensionality reduction analysis to elucidate the cross-talk between one-carbon and xenobiotic metabolic pathways in multi-disease models.
Molecular biology reports
Feb 4, 2015
Putatively functional polymorphisms of one-carbon and xenobiotic metabolic pathways influence susceptibility for wide spectrum of diseases. The current study was aimed to explore gene-gene interactions among these two metabolic pathways in four disea...
Xenobiotics
Metabolic Networks and Pathways
Factor Analysis, Statistical
Lupus Erythematosus, Systemic
Humans
Epistasis, Genetic
Coronary Artery Disease
Female
Oxidoreductases
Transferases
Polymorphism, Single Nucleotide
Sex Factors
Case-Control Studies
Multifactor Dimensionality Reduction
Breast Neoplasms
Carbon
Genetic Predisposition to Disease
Datasets as Topic
Male
Parkinson Disease
Gene Expression Regulation
UGMDR: a unified conceptual framework for detection of multifactor interactions underlying complex traits.
Heredity
Oct 22, 2014
Biological outcomes are governed by multiple genetic and environmental factors that act in concert. Determining multifactor interactions is the primary topic of interest in recent genetics studies but presents enormous statistical and mathematical ch...
Epistasis Analysis: Classification Through Machine Learning Methods.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Complex disease is different from Mendelian disorders. Its development usually involves the interaction of multiple genes or the interaction between genes and the environment (i.e. epistasis). Although the high-throughput sequencing technologies for ...
A Belief Degree-Associated Fuzzy Multifactor Dimensionality Reduction Framework for Epistasis Detection.
Methods in molecular biology (Clifton, N.J.)
Jan 1, 2021
Epistasis is a challenge in prediction, classification, and suspicion of human genetic diseases. Many technologies, methods, and tools have been developed for epistasis detection. Multifactor dimensionality reduction (MDR) is the method commonly used...
Interaction Effects of Gene Polymorphisms and Obesity on Nonalcoholic Fatty Liver Disease.
Biomedical and environmental sciences : BES
Oct 1, 2019
Multiobjective multifactor dimensionality reduction to detect SNP-SNP interactions.
Bioinformatics (Oxford, England)
Jul 1, 2018
MOTIVATION: Single-nucleotide polymorphism (SNP)-SNP interactions (SSIs) are popular markers for understanding disease susceptibility. Multifactor dimensionality reduction (MDR) can successfully detect considerable SSIs. Currently, MDR-based methods ...
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