The journal of pathology. Clinical research
Nov 14, 2022
Deep learning models are increasingly being used to interpret whole-slide images (WSIs) in digital pathology and to predict genetic mutations. Currently, it is commonly assumed that tumor regions have most of the predictive power. However, it is reas...
Biomedical physics & engineering express
Nov 11, 2022
The world health organization recommended to incorporate gene information such as isocitrate dehydrogenase 1 (IDH1) mutation status to improve prognosis, diagnosis, and treatment of the central nervous system tumors. We proposed our Shuffle Residual ...
IEEE journal of biomedical and health informatics
Nov 10, 2022
The effect of mutations has been traditionally predicted by studying what may happen due to the substitution of one amino acid for another one. This approach may be effective for mutations with impact in the function of the protein, but ineffective f...
BMC medical informatics and decision making
Nov 9, 2022
BACKGROUND: Epilepsy is the fourth-most common neurological disorder, affecting an estimated 50 million patients globally. Nearly 40% of patients have uncontrolled seizures yet incur 80% of the cost. Anti-epileptic drugs commonly result in resistance...
IEEE transactions on pattern analysis and machine intelligence
Nov 7, 2022
Fighting against the pandemic diseases with unique characters requires new sophisticated approaches like the artificial intelligence. This paper develops an artificial intelligence algorithm to produce multi-dimensional policies for controlling and m...
The number of SARS-CoV-2 spike Receptor Binding Domain (RBD) with multiple amino acid mutations is huge due to random mutations and combinatorial explosions, making it almost impossible to experimentally determine their binding affinities to human an...
A fundamental question in protein science is where allosteric hotspots - residues critical for allosteric signaling - are located, and what properties differentiate them. We carried out deep mutational scanning (DMS) of four homologous bacterial allo...
International journal of molecular sciences
Sep 29, 2022
Genes are composed of DNA and each gene has a specific sequence. Recombination or replication within the gene base ends in a permanent change in the nucleotide collection in a DNA called mutation and some mutations can lead to cancer. Breast adenocar...
International journal of molecular sciences
Sep 26, 2022
BRCA 1/2 genes mutation status can already determine the therapeutic algorithm of high grade serous ovarian cancer patients. Nevertheless, its assessment is not sufficient to identify all patients with genomic instability, since BRCA 1/2 mutations ar...
BACKGROUND: Despite the fact that tumor microenvironment (TME) and gene mutations are the main determinants of progression of the deadliest cancer in the world - lung cancer, their interrelations are not well understood. Digital pathology data provid...