AIMC Topic: Nanoparticles

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Machine learning prediction of nanoparticle in vitro toxicity: A comparative study of classifiers and ensemble-classifiers using the Copeland Index.

Toxicology letters
Nano-Particles (NPs) are well established as important components across a broad range of products from cosmetics to electronics. Their utilization is increasing with their significant economic and societal potential yet to be fully realized. Inroads...

Electrochemical protein recognition based on macromolecular self-assembly of molecularly imprinted polymer: a new strategy to mimic antibody for label-free biosensing.

Journal of materials chemistry. B
A versatile strategy, based on the use of an amphiphilic copolymer as a macromonomer, was developed for the preparation of a fully synthetic MIP (molecularly imprinted polymer) sensor for protein recognition. A UV-crosslinkable copolymer poly(DMA-co-...

Plasmonic MoO nanoparticles incorporated in Prussian blue frameworks exhibit highly efficient dual photothermal/photodynamic therapy.

Journal of materials chemistry. B
Development of near infrared (NIR) light-responsive nanomaterials for high performance multimodal phototherapy within a single nanoplatform is still challenging in technology and biomedicine. Herein, a new phototherapeutic nanoagent based on FDA-appr...

Exploration of the nanomedicine-design space with high-throughput screening and machine learning.

Nature biomedical engineering
Only a tiny fraction of the nanomedicine-design space has been explored, owing to the structural complexity of nanomedicines and the lack of relevant high-throughput synthesis and analysis methods. Here, we report a methodology for determining struct...

Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.

Artificial cells, nanomedicine, and biotechnology
In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, we have investigated the effect of chitosan-bulk (Ch-bulk), chitosan nanoparticles (ChNP), chitosan ...

Quantitative design rules for protein-resistant surface coatings using machine learning.

Scientific reports
Preventing biological contamination (biofouling) is key to successful development of novel surface and nanoparticle-based technologies in the manufacturing industry and biomedicine. Protein adsorption is a crucial mediator of the interactions at the ...

Fluorescent silicon nanoparticles inhibit the amyloid fibrillation of insulin.

Journal of materials chemistry. B
Amyloid fibrillation of proteins is likely a key factor leading to the development of amyloidosis-associated diseases. Inhibiting amyloid fibrillation has become a crucial therapeutic strategy. Water-soluble, fluorescent silicon nanoparticles (SiNPs)...

Manganese oxide nanoparticles induce genotoxicity and DNA hypomethylation in the moss Physcomitrella patens.

Mutation research. Genetic toxicology and environmental mutagenesis
The genotoxicity of nanoparticles is a major concern for nano-safety appraisal in the bryophytes as they are the primary colonizers of bare land, indicators of atmospheric pollution and excellent accumulators of trace metals. The present study for th...

Using artificial neural network to investigate physiological changes and cerium oxide nanoparticles and cadmium uptake by Brassica napus plants.

Environmental pollution (Barking, Essex : 1987)
Heavy metals and emerging engineered nanoparticles (ENPs) are two current environmental concerns that have attracted considerable attention. Cerium oxide nanoparticles (CeONPs) are now used in a plethora of industrial products, while cadmium (Cd) is ...

Etching reaction-based photoelectrochemical immunoassay of aflatoxin B in foodstuff using cobalt oxyhydroxide nanosheets-coating cadmium sulfide nanoparticles as the signal tags.

Analytica chimica acta
A new split-type photoelectrochemical (PEC) immunosensing platform was designed for sensitive detection of aflatoxin B (AFB) in foodstuffs, coupling with enzymatic hydrolysate-triggered etching reaction of cobalt oxyhydroxide (CoOOH) on cadmium sulfi...