AIMC Topic: Neoplasms
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Artificial intelligence utilization in cancer screening program across ASEAN: a scoping review.
BMC cancer
Apr 15, 2025
BACKGROUND: Cancer remains a significant health challenge in the ASEAN region, highlighting the need for effective screening programs. However, approaches, target demographics, and intervals vary across ASEAN member states, necessitating a comprehens...
Designing Clinical Trials for Patients With Rare Cancers: Connecting the Zebras.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Apr 14, 2025
The field of rare cancer research is rapidly transforming, marked by significant progress in clinical trials and treatment strategies. Rare cancers, as defined by the National Cancer Institute, occur in fewer than 150 cases per million people each ye...
Machine Learning and Structural Dynamics-Based Approach to Reveal Molecular Mechanism of PTEN Missense Mutations Shared by Cancer and Autism Spectrum Disorder.
Journal of chemical information and modeling
Apr 14, 2025
Missense mutations in oncogenic proteins that are concurrently associated with neurodevelopmental disorders have garnered significant attention. Phosphatase and tensin homologue (PTEN) serves as a paradigmatic model for mapping its mutational landsca...
Towards improved prescription metrics in novel radiotherapy techniques: a machine learning study.
Physics in medicine and biology
Apr 14, 2025
FLASH radiotherapy (RT), microbeam RT (MRT) and minibeam RT (MBRT) are novel RT techniques that have been shown to reduce normal tissue complication probabilities, by modulating the dose distributions through different parameters in space and time. T...
Deep learning-based identification of patients at increased risk of cancer using routine laboratory markers.
Scientific reports
Apr 12, 2025
Early screening for cancer has proven to improve the survival rate and spare patients from intensive and costly treatments due to late diagnosis. Cancer screening in the healthy population involves an initial risk stratification step to determine the...
Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity.
Cell
Apr 11, 2025
Chimeric antigen receptor (CAR) T cell immunotherapy represents a breakthrough in the treatment of hematological malignancies, but poor specificity has limited its applicability to solid tumors. By contrast, natural T cells harboring T cell receptors...
Development of a Machine Learning Algorithm to Predict Abnormalities in Serum Phosphate in a Large Oncology Cohort.
JCO clinical cancer informatics
Apr 11, 2025
PURPOSE: Serum phosphate is commonly measured in oncology patients because of the relationship between oncologic conditions and treatments with abnormal phosphate. All patients attending our institution, a large specialist oncology center, have a sta...
Design of Multi-Cancer VOCs Profiling Platform via a Deep Learning-Assisted Sensing Library Screening Strategy.
Analytical chemistry
Apr 10, 2025
The efficiency of sensor arrays in parallel discrimination of multianalytes is fundamentally influenced by the quantity and performance of the sensor elements. The advent of combinational design has notably accelerated the generation of chemical libr...
Smart MXene-based microrobots for targeted drug delivery and synergistic therapies.
Nanoscale
Apr 10, 2025
MXenes and their composites exhibit remarkable electrical conductivity, mechanical flexibility, and biocompatibility, making them ideal candidates for microrobot fabrication. Their tunable surface chemistry allows for easy functionalization, which en...
Portal dose image prediction using Monte Carlo generated transmission energy fluence maps of dynamic radiotherapy treatment plans: a deep learning approach.
Biomedical physics & engineering express
Apr 9, 2025
This work aims to develop and investigate the feasibility of a hybrid model combining Monte Carlo (MC) simulations and deep learning (DL) to predict electronic portal imaging device (EPID) images based on MC-generated exit phase space energy fluence ...
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