Molecular glues are a new class of tiny compounds that can rewire protein-protein interactions, providing a very selective mechanism to modify immunological signalling pathways. These substances allow immune regulators to be selectively degraded or s...
Microfluidic technologies have revolutionized the synthesis of nanocarriers for drug and gene delivery, providing unparalleled precision and efficiency in the production of therapeutic nanoparticles. This review highlights recent advancements in micr...
Journal of controlled release : official journal of the Controlled Release Society
Oct 22, 2025
The design of ultrasound (US)-responsive nanocarriers (URNs) guided by their physicochemical characteristics represents a pivotal strategy for advancing cancer therapy. By exploiting the intrinsic physicochemical properties of diverse nanocarriers, i...
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Oct 17, 2025
Recent evidence from the CHALLENGE trial confirms that structured exercise can significantly improve survival outcomes in colon cancer survivors, reinforcing the principle that exercise is medicine. However, implementing personalized and scalable reh...
Active mobile elements in the human genome can create novel mobile element insertions (MEIs) in somatic tissues. Detection of somatic MEIs, particularly those with low mosaicism, remains a significant challenge due to sequencing artifacts and alignme...
Medical oncology (Northwood, London, England)
Oct 16, 2025
Metastatic cancer is the leading cause of cancer-related mortality, responsible for nearly 90% of deaths worldwide. Its progression depends on a multistep cascade involving invasion, vascular dissemination, survival in circulation and colonization of...
N -methyladenosine (m A), the most prevalent internal modification in eukaryotic RNAs, has emerged as a focal point of intensive research in recent years owing to its pivotal regulatory roles in carcinogenesis, progression, and metastasis. However, c...
Journal of chemical information and modeling
Oct 10, 2025
Phosphorylation dynamically orchestrates the protein-protein interaction (PPI) network that governs cellular signaling, and its dysregulation frequently drives malignant transformation and neurodegeneration. We present PhosPPI-SEQ, an interpretable d...
Journal of chemical information and modeling
Oct 10, 2025
Effective anticancer drug combinations are crucial for advancing cancer treatment, yet predicting drug synergy remains challenging due to the complexity of biological interactions. Existing methods struggle to integrate multimodal features and to mod...
DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large datasets to identi...
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