BACKGROUND: Cancer survivors and their caregivers, particularly those from disadvantaged backgrounds with limited health literacy or racial and ethnic minorities facing language barriers, are at a disproportionately higher risk of experiencing sympto...
OBJECTIVES: The emergence of large language models has resulted in a significant shift in informatics research and carries promise in clinical cancer care. Here we provide a narrative review of the recent use of large language models (LLMs) to suppor...
INTRODUCTION: Epigenetic biomarkers are molecular indicators of epigenetic changes, and some studies have suggested that these biomarkers have predictive power for disease risk. This study aims to analyze the relationship between 30 epigenetic biomar...
Synthetic lethality (SL) is a promising gene interaction for cancer therapy. Recent SL prediction methods integrate knowledge graphs (KGs) into graph neural networks (GNNs) and employ attention mechanisms to extract local subgraphs as explanations fo...
Drug response prediction (DRP) methods tackle the complex task of associating the effectiveness of small molecules with the specific genetic makeup of the patient. Anti-cancer DRP is a particularly challenging task requiring costly experiments as und...
European journal of clinical investigation
40191923
BACKGROUND: The management of cardiotoxicity related to cancer therapies has emerged as a significant clinical challenge, prompting the rapid growth of cardio-oncology. As cancer treatments become more complex, there is an increasing need to enhance ...
Hyperthermia (HT) in combination with radio- and/or chemotherapy has become an accepted cancer treatment for distinct solid tumour entities. In HT, tumour tissue is exogenously heated to temperatures between 39 and 43 °C for 60 min. Temperature monit...
BACKGROUND: Lysyl oxidases (LOX/LOXL1-4) are crucial for cancer progression, yet their transcriptional regulation, potential therapeutic targeting, prognostic value and involvement in immune regulation remain poorly understood. This study comprehensi...
FLASH radiotherapy (RT), microbeam RT (MRT) and minibeam RT (MBRT) are novel RT techniques that have been shown to reduce normal tissue complication probabilities, by modulating the dose distributions through different parameters in space and time. T...
PURPOSE: This study aimed to differentiate nonscheduled visits (NSVs) in an outpatient palliative care setting that are driven by or accompanied by uncontrolled symptoms from those that are administrative or routine, such as prescription refills and ...