BACKGROUND: Small pancreatic neuroendocrine tumors (PNETs) are a unique subset of pancreatic neoplasms. Chromogranin A (CgA) levels, mitotic rate, and histologic differentiation are often used to characterize PNET behavior. This study evaluates the i...
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
28083567
Robust and accurate nuclei localization in microscopy image can provide crucial clues for accurate computer-aid diagnosis. In this paper, we propose a convolutional neural network (CNN) based hough voting method to localize nucleus centroids with hea...
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention
27924317
Efficient and effective cell segmentation of neuroendocrine tumor (NET) in whole slide scanned images is a difficult task due to a large number of cells. The weak or misleading cell boundaries also present significant challenges. In this paper, we pr...
Efficient and robust cell detection serves as a critical prerequisite for many subsequent biomedical image analysis methods and computer-aided diagnosis (CAD). It remains a challenging task due to touching cells, inhomogeneous background noise, and l...
The World Health Organization (WHO) has clear guidelines regarding the use of Ki67 index in defining the proliferative rate and assigning grade for pancreatic neuroendocrine tumor (NET). WHO mandates the quantification of Ki67 index by counting at le...
IEEE transactions on bio-medical engineering
30802845
OBJECTIVE: Nucleus recognition is a critical yet challenging step in histopathology image analysis, for example, in Ki67 immunohistochemistry stained images. Although many automated methods have been proposed, most use a multi-stage processing pipeli...