Since the variables inherent to various diseases cannot be controlled directly in humans, behavioral dysfunctions have been examined in model organisms, leading to better understanding their underlying mechanisms. However, because the spatial and tem...
OBJECTIVE: This study aimed to develop an automatic classifier to distinguish different motor subtypes of Parkinson's disease (PD) based on multilevel indices of resting-state functional magnetic resonance imaging (rs-fMRI).
Neurodegenerative diseases (NDs) are characterized by progressive neuronal dysfunction and death of brain cells population. As the early manifestations of NDs are similar, their symptoms are difficult to distinguish, making the timely detection and d...
Conventional approaches to diagnosing Parkinson's disease (PD) and rating its severity level are based on medical specialists' clinical assessment of symptoms, which are subjective and can be inaccurate. These techniques are not very reliable, partic...
BACKGROUND: Parkinson's disease is heterogeneous in symptom presentation and progression. Increased understanding of both aspects can enable better patient management and improve clinical trial design. Previous approaches to modelling Parkinson's dis...
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Jul 28, 2021
OBJECTIVE: Early postural instability (PI) is a red flag for the diagnosis of Parkinson's disease (PD). Several patients, however, fall within the first three years of disease, particularly when turning. We investigated whether PD patients, without c...
International journal of computer assisted radiology and surgery
Jul 3, 2021
PURPOSE: Deep Brain Stimulation (DBS) is a proven therapy for Parkinson's Disease (PD), frequently resulting in an enhancement of motor function. Nonetheless, several undesirable side effects can occur after DBS, which can worsen the quality of life ...
Background Group comparison results associating cortical thinning and Parkinson disease (PD) dementia (PDD) are limited in their application to clinical settings. Purpose To investigate whether cortical thickness from MRI can help predict conversion ...
Commonly used for Parkinson's disease (PD), deep brain stimulation (DBS) produces marked clinical benefits when optimized. However, assessing the large number of possible stimulation settings (i.e., programming) requires numerous clinic visits. Here,...
BACKGROUND: Parkinson's disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances. The correct diagnosis, especially in the initi...