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Parkinson Disease

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An efficient ranking-based ensembled multiclassifier for neurodegenerative diseases classification using deep learning.

Journal of neural transmission (Vienna, Austria : 1996)
Neurodegenerative diseases are group of debilitating and progressive disorders that primarily affect the structure and functions of nervous system, leading to gradual loss of neurons and subsequent decline in cognitive, and behavioral activities. The...

Enhancing early Parkinson's disease detection through multimodal deep learning and explainable AI: insights from the PPMI database.

Scientific reports
Parkinson's is the second most common neurodegenerative disease, affecting nearly 8.5M people and steadily increasing. In this research, Multimodal Deep Learning is investigated for the Prodromal stage detection of Parkinson's Disease (PD), combining...

Houston, We Have AI Problem! Quality Issues with Neuroimaging-Based Artificial Intelligence in Parkinson's Disease: A Systematic Review.

Movement disorders : official journal of the Movement Disorder Society
In recent years, many neuroimaging studies have applied artificial intelligence (AI) to facilitate existing challenges in Parkinson's disease (PD) diagnosis, prognosis, and intervention. The aim of this systematic review was to provide an overview of...

Higher Order Polynomial Transformer for Fine-Grained Freezing of Gait Detection.

IEEE transactions on neural networks and learning systems
Freezing of Gait (FoG) is a common symptom of Parkinson's disease (PD), manifesting as a brief, episodic absence, or marked reduction in walking, despite a patient's intention to move. Clinical assessment of FoG events from manual observations by exp...

Auxiliary diagnostic method of Parkinson's disease based on eye movement analysis in a virtual reality environment.

Neuroscience letters
Eye movement dysfunction is one of the non-motor symptoms of Parkinson's disease (PD). An accurate analysis method for eye movement is an effective way to gain a deeper understanding of the nervous system function of PD patients. However, currently, ...

Automated Sleep Detection in Movement Disorders Using Deep Brain Stimulation and Machine Learning.

Movement disorders : official journal of the Movement Disorder Society
BACKGROUND: Automated sleep detection in movement disorders may allow monitoring sleep, potentially guiding adaptive deep brain stimulation (DBS).

Metabolomics Unveils Disrupted Pathways in Parkinson's Disease: Toward Biomarker-Based Diagnosis.

ACS chemical neuroscience
Parkinson's disease (PD) is a neurodegenerative disorder characterized by diverse symptoms, where accurate diagnosis remains challenging. Traditional clinical observation methods often result in misdiagnosis, highlighting the need for biomarker-based...

Deep Learning and fMRI-Based Pipeline for Optimization of Deep Brain Stimulation During Parkinson's Disease Treatment: Toward Rapid Semi-Automated Stimulation Optimization.

IEEE journal of translational engineering in health and medicine
OBJECTIVE: Optimized deep brain stimulation (DBS) is fast becoming a therapy of choice for the treatment of Parkinson's disease (PD). However, the post-operative optimization (aimed at maximizing patient clinical benefits and minimizing adverse effec...

What the trained eye cannot see: Quantitative kinematics and machine learning detect movement deficits in early-stage Parkinson's disease from videos.

Parkinsonism & related disorders
BACKGROUND: Evaluation of disease severity in Parkinson's disease (PD) relies on motor symptoms quantification. However, during early-stage PD, these symptoms are subtle and difficult to quantify by experts, which might result in delayed diagnosis an...

Machine learning and wearable sensors for automated Parkinson's disease diagnosis aid: a systematic review.

Journal of neurology
BACKGROUND: The diagnosis of Parkinson's disease is currently based on clinical evaluation. Despite clinical hallmarks, unfortunately, the error rate is still significant. Low in-vivo diagnostic accuracy of clinical evaluation mainly relies on the la...