AIMC Topic: Particle Size
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Preparation and optimisation of solid lipid nanoparticles of rivaroxaban using artificial neural networks and response surface method.
Journal of microencapsulation
Jan 5, 2025
AIMS: This study aimed to improve rivaroxaban delivery by optimising solid lipid nanoparticles (SLN) for minimal mean diameter and maximal entrapment efficiency (EE), enhancing solubility, bioavailability, and the ability to cross the blood-brain bar...
Antibacterial effects of thyme oil loaded solid lipid and chitosan nano-carriers against Salmonella Typhimurium and Escherichia coli as food preservatives.
PloS one
Dec 31, 2024
OBJECTIVES: Escherichia coli and Salmonella Typhimurium are frequent causes of foodborne illness affecting many people annually. In order to develop natural antimicrobial agents against these microorganisms, thyme oil (TO) was considered as active an...
Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management.
Drug design, development and therapy
Dec 19, 2024
PURPOSE: Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast ca...
Improving WRF-Chem PM predictions by combining data assimilation and deep-learning-based bias correction.
Environment international
Dec 15, 2024
In numerical model simulations, data assimilation (DA) on the initial conditions and bias correction (BC) of model outputs have been proven to be promising approaches to improving PM (particulate matter with an aerodynamic equivalent diameter of ≤ 2....
High-Speed Imaging-Based Particle Attribute Analysis of Spray-Dried Amorphous Solid Dispersions Using a Convolution Neural Network.
Molecular pharmaceutics
Dec 2, 2024
Spray drying is a well-established method for preparing amorphous solid dispersion (ASD) formulations to improve the oral bioavailability of poorly soluble drugs. In addition to the characterization of the amorphous phase, particle attributes of spra...
Application of one-class classification using deep learning technique improves the classification of subvisible particles.
Journal of pharmaceutical sciences
Nov 29, 2024
Capturing subvisible particles using flow imaging microscopy is useful for evaluating protein aggregates that may induce immunogenicity. Automated labeling is desirable to distinguish harmless components such as silicone oil (SO) from subvisible part...
Improving PM and PM predictions in China from WRF_Chem through a deep learning method: Multiscale depth-separable UNet.
Environmental pollution (Barking, Essex : 1987)
Nov 21, 2024
Accurate predictions of atmospheric particulate matter can be applied in providing services for air pollution prevention and control. However, the forecasting accuracy of traditional air quality models is limited owing to model uncertainties. In this...
Machine learning strengthened formulation design of pharmaceutical suspensions.
International journal of pharmaceutics
Nov 19, 2024
Many different formulation strategies have been investigated to oppose suboptimal treatment of long-term or chronic conditions, one of which are the nano- and microsuspensions prepared as long-acting injectables to prolong the release of an active ph...
High-throughput point-of-care serum iron testing utilizing machine learning-assisted deep eutectic solvent fluorescence detection platform.
Journal of colloid and interface science
Nov 17, 2024
In this study, a high-throughput point-of-care testing (HT-POCT) system for detecting serum iron was developed using a hydrophobic deep eutectic solvent (HDES) fluorescence detection platform. This machine learning-assisted portable platform enables ...
In silico formulation optimization and particle engineering of pharmaceutical products using a generative artificial intelligence structure synthesis method.
Nature communications
Nov 7, 2024
Pharmaceutical drug dosage forms are critical for ensuring the effective and safe delivery of active pharmaceutical ingredients to patients. However, traditional formulation development often relies on extensive lab and animal experimentation, which ...
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