The transfection potency and biological fate of gene-loaded lipid nanoparticles (LNPs) are often determined by their morphological and physicochemical properties. Cryogenic-electron microscopy (cryo-EM) remains the most effective tool to analyze LNP ...
Journal of colloid and interface science
Sep 6, 2025
Developing high-performance wearable flexible sensors that can adapt well to complex environments has become a hotspot. Herein, a polyvinyl alcohol based composite hydrogel sensor with high mechanical strength, desirable frost/swelling resistance, an...
Biosimilar artificial mucus models that mimic native mucus facilitate efficient, lab-based drug diffusion studies, addressing the costly and challenging preclinical phase of drug development, especially for nano- and micro-scale particle-based coloni...
International journal of pharmaceutics
Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
Previous air pollution modeling studies have predominantly emphasized horizontal distributions, overlooking the critical vertical variability of pollutant concentrations in urban environments. Therefore, the three-dimensional (3-D) behavior of air po...
Label-free optical imaging of the morphology of single nanoparticles under native conditions remains a challenging task despite its importance in the synthesis, properties, and applications of nanomaterials. Here, we developed an angular scanning dar...
This study employed multiple machine learning (ML) methods to model and predict key attributes of PLGA nanoparticles, specifically particle size and zeta potential. The predictions were based on input variables, including PLGA polymer type, PLGA conc...
Emulsifiers maintain the stability of emulsions, and milk protein-formed emulsions are unstable. Hence, efficient ways to screen food-derived compounds need to be identified. This study combined molecular descriptors with machine learning algorithms ...
Ecotoxicology and environmental safety
Jun 5, 2025
Particulate matter (PM) is a recognized carcinogen, but the effects of PM on liver cancer remain underexplored. This study investigates the long-term association between PM and liver cancer mortality, as well as the contribution of smaller particles ...
Current clinical treatment of pulmonary diseases requires an advanced three-dimensional (3D) pathological atlas of the microenvironment, particularly the trachea, which is predominantly affected by lung disorders. In this study, the gridded cyclodext...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.