AIMC Topic: Pharmacogenetics

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PharmGKB Tutorial for Pharmacogenomics of Drugs Potentially Used in the Context of COVID-19.

Clinical pharmacology and therapeutics Oct 24, 2020
Pharmacogenomics (PGx) is a key area of precision medicine, which is already being implemented in some health systems and may help guide clinicians toward effective therapies for individual patients. Over the last 2 decades, the Pharmacogenomics Know...
Humans COVID-19 Precision Medicine COVID-19 Drug Treatment Gene Ontology Medication Therapy Management Pharmacogenomic Testing Pharmacogenetics Antiviral Agents Knowledge Bases
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Precision psychiatry in clinical practice.

International journal of psychiatry in clinical practice Aug 27, 2020
The treatment of depression represents a major challenge for healthcare systems and choosing among the many available drugs without objective guidance criteria is an error-prone process. Recently, pharmacogenetic biomarkers entered in prescribing gui...
Drug Monitoring Antidepressive Agents Depressive Disorder Humans Artificial Intelligence Psychiatry Precision Medicine Pharmacogenetics
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Beyond the limitation of targeted therapy: Improve the application of targeted drugs combining genomic data with machine learning.

Pharmacological research May 28, 2020
Precision oncology involves effectively selecting drugs for cancer patients and planning an effective treatment regimen. However, for Molecular targeted drug, using genomic state of the drug target to select drugs has limitations. Many patients who c...
Humans Machine Learning Decision Support Techniques Neoplasms Antineoplastic Agents Pharmacogenetics Cell Line, Tumor Precision Medicine Clinical Decision-Making Biomarkers, Tumor Molecular Targeted Therapy Databases, Genetic Models, Statistical Drug Screening Assays, Antitumor Genomics Gene Expression Regulation, Neoplastic Signal Transduction
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Precision Psychiatry Applications with Pharmacogenomics: Artificial Intelligence and Machine Learning Approaches.

International journal of molecular sciences Feb 1, 2020
A growing body of evidence now suggests that precision psychiatry, an interdisciplinary field of psychiatry, precision medicine, and pharmacogenomics, serves as an indispensable foundation of medical practices by offering the accurate medication with...
Precision Medicine Pharmacogenetics Interdisciplinary Studies Humans Neural Networks, Computer Artificial Intelligence Machine Learning Algorithms Mental Disorders
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PGxCorpus, a manually annotated corpus for pharmacogenomics.

Scientific data Jan 2, 2020
Pharmacogenomics (PGx) studies how individual gene variations impact drug response phenotypes, which makes PGx-related knowledge a key component towards precision medicine. A significant part of the state-of-the-art knowledge in PGx is accumulated in...
Supervised Machine Learning PubMed Data Curation Humans Pharmacogenetics
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PharmVar GeneFocus: CYP2D6.

Clinical pharmacology and therapeutics Dec 9, 2019
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocu...
Cytochrome P-450 CYP2D6 Humans Pharmacogenetics Databases, Genetic Genetic Variation Polymorphism, Genetic Pharmaceutical Preparations Knowledge Bases
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The Clinical Pharmacogenetics Implementation Consortium: 10 Years Later.

Clinical pharmacology and therapeutics Nov 5, 2019
In 2009, the Clinical Pharmacogenetics Implementation Consortium (CPIC, www.cpicpgx.org), a shared project between Pharmacogenomics Knowledge Base (PharmGKB, http://www.pharmgkb.org) and the National Institutes of Health (NIH), was created to provide...
Humans Pharmacogenetics Databases, Factual Knowledge Bases Electronic Health Records Practice Guidelines as Topic
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PGxO and PGxLOD: a reconciliation of pharmacogenomic knowledge of various provenances, enabling further comparison.

BMC bioinformatics Apr 18, 2019
BACKGROUND: Pharmacogenomics (PGx) studies how genomic variations impact variations in drug response phenotypes. Knowledge in pharmacogenomics is typically composed of units that have the form of ternary relationships gene variant - drug - adverse ev...
Databases, Factual Electronic Health Records Pharmacogenetics Knowledge Bases Data Mining Tissue Banks Humans
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Contemporary pharmacogenetic assays in view of the PharmGKB database.

Pharmacogenomics Mar 18, 2019
AIM: Six modern PGx assays were compared with the Pharmacogenomics Knowledge Base (PharmGKB) to determine the proportion of the currently known PGx genotypes that are assessed by these assays.
Knowledge Bases Pharmacogenomic Testing Databases, Factual Pharmacogenetics Genotype Humans
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Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Thrombosis Hemorrhage Drug Administration Schedule Genotype Aged, 80 and over Anticoagulants Male Databases, Factual Humans Warfarin Middle Aged Female Machine Learning Medical Errors Multivariate Analysis Aged Algorithms International Cooperation Vitamin K Epoxide Reductases Pharmacogenetics Linkage Disequilibrium Cohort Studies Polymorphism, Single Nucleotide
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