AIMC Topic: Verapamil
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Machine learning predicts cerebral vasospasm in patients with subarachnoid haemorrhage.
EBioMedicine
Jun 19, 2024
BACKGROUND: Cerebral vasospasm (CV) is a feared complication which occurs after 20-40% of subarachnoid haemorrhage (SAH). It is standard practice to admit patients with SAH to intensive care for an extended period of resource-intensive monitoring. We...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Neural Networks, Computer
Algorithms
Computer Simulation
Nanoparticles
Particle Size
Lipids
Drug Carriers
Models, Chemical
Polymers
Kinetics
Verapamil
Solubility
Nanomedicine
Technology, Pharmaceutical
Surface Properties
Calcium Channel Blockers
Chemistry, Pharmaceutical
Delayed-Action Preparations
Poloxamer
Polysorbates
Antihypertensive Activity of Sauromatum guttatum Mediated by Vasorelaxation and Myocardial Depressant Effects.
Arquivos brasileiros de cardiologia
Dec 1, 2021
BACKGROUND: Sauromatum guttatum (S. guttatum) is used in the treatment of blood disorders and reportedly has a spasmolytic activity through Ca2+ channel inhibition.
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